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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE3B
All Species:
11.52
Human Site:
S280
Identified Species:
23.03
UniProt:
Q13370
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13370
NP_000913.2
1112
124333
S280
P
L
H
P
R
L
S
S
A
A
E
E
K
V
P
Chimpanzee
Pan troglodytes
XP_520783
1141
125048
Q274
P
R
E
H
L
G
S
Q
L
I
A
G
T
K
E
Rhesus Macaque
Macaca mulatta
XP_001092891
1117
125088
S280
P
L
H
P
R
L
S
S
A
A
E
E
K
V
P
Dog
Lupus familis
XP_854529
779
87136
R20
L
S
V
L
N
E
A
R
N
M
V
S
D
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61409
1100
122135
S258
S
P
P
P
R
S
A
S
T
A
E
E
K
V
P
Rat
Rattus norvegicus
Q63085
1108
123088
S264
S
P
P
P
R
S
A
S
T
A
D
E
K
V
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518516
340
38206
Chicken
Gallus gallus
NP_001026353
1105
121291
G271
R
G
I
F
P
E
R
G
R
A
E
H
Q
Q
H
Frog
Xenopus laevis
NP_001088828
985
108702
Y226
D
W
D
L
K
Q
W
Y
K
P
Q
Y
Q
N
A
Zebra Danio
Brachydanio rerio
XP_691883
1107
124050
P254
R
E
S
A
G
R
V
P
N
A
E
E
K
V
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q8I0P7
625
69850
Sea Urchin
Strong. purpuratus
XP_793920
1558
171759
L614
G
G
G
L
I
S
G
L
T
R
S
S
M
T
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42
96.7
60.6
N.A.
81.5
80.6
N.A.
22.4
63.6
59.7
63.2
N.A.
N.A.
N.A.
26.5
28.2
Protein Similarity:
100
58.2
98.2
64.5
N.A.
86.9
86.7
N.A.
26.9
75
70.8
75.5
N.A.
N.A.
N.A.
38.2
41.8
P-Site Identity:
100
13.3
100
0
N.A.
60
53.3
N.A.
0
13.3
0
40
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
13.3
100
13.3
N.A.
66.6
66.6
N.A.
0
20
20
40
N.A.
N.A.
N.A.
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
25
0
17
50
9
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
9
0
0
0
0
0
0
0
9
0
9
0
0
% D
% Glu:
0
9
9
0
0
17
0
0
0
0
42
42
0
0
9
% E
% Phe:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
17
9
0
9
9
9
9
0
0
0
9
0
0
0
% G
% His:
0
0
17
9
0
0
0
0
0
0
0
9
0
0
9
% H
% Ile:
0
0
9
0
9
0
0
0
0
9
0
0
0
0
0
% I
% Lys:
0
0
0
0
9
0
0
0
9
0
0
0
42
9
0
% K
% Leu:
9
17
0
25
9
17
0
9
9
0
0
0
0
9
9
% L
% Met:
0
0
0
0
0
0
0
0
0
9
0
0
9
0
0
% M
% Asn:
0
0
0
0
9
0
0
0
17
0
0
0
0
9
0
% N
% Pro:
25
17
17
34
9
0
0
9
0
9
0
0
0
0
42
% P
% Gln:
0
0
0
0
0
9
0
9
0
0
9
0
17
9
0
% Q
% Arg:
17
9
0
0
34
9
9
9
9
9
0
0
0
0
9
% R
% Ser:
17
9
9
0
0
25
25
34
0
0
9
17
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
25
0
0
0
9
9
0
% T
% Val:
0
0
9
0
0
0
9
0
0
0
9
0
0
42
0
% V
% Trp:
0
9
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _