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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE3B All Species: 4.55
Human Site: S495 Identified Species: 9.09
UniProt: Q13370 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13370 NP_000913.2 1112 124333 S495 I P K Q R S S S V S L T H H V
Chimpanzee Pan troglodytes XP_520783 1141 125048 A498 R S F T S S Y A I S A A N H V
Rhesus Macaque Macaca mulatta XP_001092891 1117 125088 S495 I P K Q R S S S V S L T H H V
Dog Lupus familis XP_854529 779 87136 Q227 P N S P D I Y Q Q L R N S D S
Cat Felis silvestris
Mouse Mus musculus Q61409 1100 122135 R471 L F T I P K Q R S S S V S L T
Rat Rattus norvegicus Q63085 1108 123088 R477 L M T I P K Q R S S S V S L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518516 340 38206
Chicken Gallus gallus NP_001026353 1105 121291 H483 N V S S Q G S H S N G S F G A
Frog Xenopus laevis NP_001088828 985 108702 V433 D F L T K P S V T L H K T A G
Zebra Danio Brachydanio rerio XP_691883 1107 124050 L473 Q R S S S V T L S Y G H T L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q8I0P7 625 69850 L73 T S L P A N S L S L N G A K V
Sea Urchin Strong. purpuratus XP_793920 1558 171759 P859 L G Q R S P S P N L M P P D G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 42 96.7 60.6 N.A. 81.5 80.6 N.A. 22.4 63.6 59.7 63.2 N.A. N.A. N.A. 26.5 28.2
Protein Similarity: 100 58.2 98.2 64.5 N.A. 86.9 86.7 N.A. 26.9 75 70.8 75.5 N.A. N.A. N.A. 38.2 41.8
P-Site Identity: 100 26.6 100 0 N.A. 6.6 6.6 N.A. 0 6.6 6.6 0 N.A. N.A. N.A. 13.3 6.6
P-Site Similarity: 100 46.6 100 0 N.A. 13.3 13.3 N.A. 0 26.6 13.3 6.6 N.A. N.A. N.A. 20 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 9 0 0 9 0 0 9 9 9 9 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 9 0 0 0 0 0 0 0 0 17 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 17 9 0 0 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 0 9 0 0 0 9 0 0 0 0 17 9 0 9 17 % G
% His: 0 0 0 0 0 0 0 9 0 0 9 9 17 25 0 % H
% Ile: 17 0 0 17 0 9 0 0 9 0 0 0 0 0 0 % I
% Lys: 0 0 17 0 9 17 0 0 0 0 0 9 0 9 0 % K
% Leu: 25 0 17 0 0 0 0 17 0 34 17 0 0 25 0 % L
% Met: 0 9 0 0 0 0 0 0 0 0 9 0 0 0 0 % M
% Asn: 9 9 0 0 0 9 0 0 9 9 9 9 9 0 0 % N
% Pro: 9 17 0 17 17 17 0 9 0 0 0 9 9 0 0 % P
% Gln: 9 0 9 17 9 0 17 9 9 0 0 0 0 0 0 % Q
% Arg: 9 9 0 9 17 0 0 17 0 0 9 0 0 0 0 % R
% Ser: 0 17 25 17 25 25 50 17 42 42 17 9 25 0 17 % S
% Thr: 9 0 17 17 0 0 9 0 9 0 0 17 17 0 17 % T
% Val: 0 9 0 0 0 9 0 9 17 0 0 17 0 0 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 17 0 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _