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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLD1 All Species: 13.03
Human Site: S540 Identified Species: 19.11
UniProt: Q13393 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13393 NP_001123553.1 1074 124184 S540 Q N L P I Q K S I D D V D S K
Chimpanzee Pan troglodytes XP_526380 1125 128795 S600 T S G P S L G S L P P A A M E
Rhesus Macaque Macaca mulatta XP_001085464 1074 124020 S540 Q N L P I R N S V D D V D S K
Dog Lupus familis XP_545291 1075 123911 S541 K N V P T S K S V D D M D S K
Cat Felis silvestris
Mouse Mus musculus Q9Z280 1074 123950 I540 K K E P I S K I V D E T D M K
Rat Rattus norvegicus P70496 1074 123795 S540 K N E P V L K S V N D T D M K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513744 295 33781
Chicken Gallus gallus XP_422793 1072 123414 D539 H L F Q K S A D D V P D I S K
Frog Xenopus laevis NP_001129642 1039 119219 K515 Q S T T A I N K I P S D P T L
Zebra Danio Brachydanio rerio NP_001153567 1022 117847 R497 T D V G S V T R S V A Q A I E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001137610 1364 155352 P786 K E R P P S P P P D E P N T S
Honey Bee Apis mellifera XP_001121004 1135 129725 N568 L P L A I A T N T V V M A T T
Nematode Worm Caenorhab. elegans NP_494939 1427 163517 N849 N T L E K E K N K K E L R R A
Sea Urchin Strong. purpuratus XP_784455 790 90080 A330 E D V P D G R A K Q A R N Q N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9M9W8 1046 118792 G508 D T A E H K I G D C P P Y I W
Baker's Yeast Sacchar. cerevisiae P36126 1683 195185 V725 E L Y L R R P V K G N Q G F R
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.7 97.8 91 N.A. 91 90.6 N.A. 22 79.4 75.6 66.6 N.A. 34.8 40.3 35.9 35.1
Protein Similarity: 100 92 99 95.1 N.A. 95.6 95.6 N.A. 24.8 88.8 86.3 78.3 N.A. 50.9 57.7 51 49.5
P-Site Identity: 100 13.3 80 60 N.A. 40 46.6 N.A. 0 13.3 13.3 0 N.A. 13.3 13.3 13.3 6.6
P-Site Similarity: 100 33.3 93.3 86.6 N.A. 60 73.3 N.A. 0 13.3 26.6 20 N.A. 40 33.3 40 46.6
Percent
Protein Identity: N.A. N.A. N.A. 30.6 21 N.A.
Protein Similarity: N.A. N.A. N.A. 50.6 35.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 7 7 7 7 7 0 0 13 7 19 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % C
% Asp: 7 13 0 0 7 0 0 7 13 32 25 13 32 0 0 % D
% Glu: 13 7 13 13 0 7 0 0 0 0 19 0 0 0 13 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 7 7 0 7 7 7 0 7 0 0 7 0 0 % G
% His: 7 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 25 7 7 7 13 0 0 0 7 13 0 % I
% Lys: 25 7 0 0 13 7 32 7 19 7 0 0 0 0 38 % K
% Leu: 7 13 25 7 0 13 0 0 7 0 0 7 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 13 0 19 0 % M
% Asn: 7 25 0 0 0 0 13 13 0 7 7 0 13 0 7 % N
% Pro: 0 7 0 50 7 0 13 7 7 13 19 13 7 0 0 % P
% Gln: 19 0 0 7 0 7 0 0 0 7 0 13 0 7 0 % Q
% Arg: 0 0 7 0 7 13 7 7 0 0 0 7 7 7 7 % R
% Ser: 0 13 0 0 13 25 0 32 7 0 7 0 0 25 7 % S
% Thr: 13 13 7 7 7 0 13 0 7 0 0 13 0 19 7 % T
% Val: 0 0 19 0 7 7 0 7 25 19 7 13 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 7 0 0 0 0 0 0 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _