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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FKBP5
All Species:
35.76
Human Site:
S249
Identified Species:
56.19
UniProt:
Q13451
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13451
NP_001139247.1
457
51212
S249
I
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Chimpanzee
Pan troglodytes
XP_001172411
457
51122
S249
I
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Rhesus Macaque
Macaca mulatta
XP_001098079
459
51670
S251
K
Y
E
L
H
L
K
S
F
E
K
A
K
E
S
Dog
Lupus familis
XP_538880
456
51014
S249
I
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Cat
Felis silvestris
Mouse
Mus musculus
Q64378
456
50948
S249
M
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Rat
Rattus norvegicus
Q9QVC8
458
51432
S251
R
Y
E
V
H
L
K
S
F
E
K
A
K
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512517
419
46551
S216
I
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Chicken
Gallus gallus
NP_001005431
449
50409
S249
V
Y
E
V
T
L
K
S
F
E
K
A
K
E
S
Frog
Xenopus laevis
NP_001084593
447
50080
N247
Q
Y
D
I
R
L
K
N
F
E
K
A
K
E
S
Zebra Danio
Brachydanio rerio
NP_998314
453
51464
D249
L
Y
E
V
T
L
K
D
F
E
K
A
K
E
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VL78
439
48777
V229
N
A
T
V
E
Y
T
V
K
L
V
D
C
G
K
Honey Bee
Apis mellifera
XP_395748
459
51510
K231
V
E
Y
I
V
E
L
K
N
F
E
K
V
E
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781282
422
47590
S236
K
S
K
Y
A
Y
G
S
Q
G
K
A
E
Y
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001141458
458
51432
S251
R
Y
E
V
H
L
K
S
F
E
K
A
K
A
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q38931
551
61434
K300
V
K
V
K
L
I
G
K
L
Q
D
G
T
V
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
54
95.1
N.A.
87
53.7
N.A.
69.8
83.1
55.5
58.6
N.A.
39.3
47
N.A.
44.2
Protein Similarity:
100
99.7
73.8
96.7
N.A.
91.6
72.4
N.A.
77.6
88.8
70.9
75.2
N.A.
56.6
61.2
N.A.
62.8
P-Site Identity:
100
100
80
100
N.A.
93.3
80
N.A.
100
93.3
66.6
80
N.A.
6.6
6.6
N.A.
20
P-Site Similarity:
100
100
86.6
100
N.A.
100
80
N.A.
100
100
86.6
93.3
N.A.
6.6
26.6
N.A.
40
Percent
Protein Identity:
N.A.
53.7
N.A.
30.1
N.A.
N.A.
Protein Similarity:
N.A.
72.4
N.A.
47
N.A.
N.A.
P-Site Identity:
N.A.
80
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
80
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
0
0
0
0
0
0
80
0
14
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
7
0
0
0
0
7
0
0
7
7
0
0
0
% D
% Glu:
0
7
67
0
7
7
0
0
0
74
7
0
7
67
0
% E
% Phe:
0
0
0
0
0
0
0
0
74
7
0
0
0
0
7
% F
% Gly:
0
0
0
0
0
0
14
0
0
7
0
7
0
7
0
% G
% His:
0
0
0
0
20
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
27
0
0
14
0
7
0
0
0
0
0
0
0
0
0
% I
% Lys:
14
7
7
7
0
0
74
14
7
0
80
7
74
0
7
% K
% Leu:
7
0
0
7
7
74
7
0
7
7
0
0
0
0
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
7
7
0
0
0
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% Q
% Arg:
14
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
7
0
0
0
0
0
67
0
0
0
0
0
0
67
% S
% Thr:
0
0
7
0
47
0
7
0
0
0
0
0
7
0
7
% T
% Val:
20
0
7
67
7
0
0
7
0
0
7
0
7
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
74
7
7
0
14
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _