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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FKBP5 All Species: 41.52
Human Site: Y243 Identified Species: 65.24
UniProt: Q13451 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13451 NP_001139247.1 457 51212 Y243 E P N A E L I Y E V T L K S F
Chimpanzee Pan troglodytes XP_001172411 457 51122 Y243 E P N A E L I Y E V T L K S F
Rhesus Macaque Macaca mulatta XP_001098079 459 51670 Y245 P P N A E L K Y E L H L K S F
Dog Lupus familis XP_538880 456 51014 Y243 E P N A E L I Y E V T L K S F
Cat Felis silvestris
Mouse Mus musculus Q64378 456 50948 Y243 D P N A E L M Y E V T L K S F
Rat Rattus norvegicus Q9QVC8 458 51432 Y245 P P H A E L R Y E V H L K S F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512517 419 46551 Y210 E P N A K L I Y E V T L K S F
Chicken Gallus gallus NP_001005431 449 50409 Y243 Q A N A E L V Y E V T L K S F
Frog Xenopus laevis NP_001084593 447 50080 Y241 P P G A E L Q Y D I R L K N F
Zebra Danio Brachydanio rerio NP_998314 453 51464 Y243 G S N A E L L Y E V T L K D F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VL78 439 48777 A223 E F K I P P N A T V E Y T V K
Honey Bee Apis mellifera XP_395748 459 51510 E225 I P P N A T V E Y I V E L K N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781282 422 47590 S230 V A R L K V K S K Y A Y G S Q
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001141458 458 51432 Y245 P P H A E L R Y E V H L K S F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q38931 551 61434 K294 P N E G A V V K V K L I G K L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 54 95.1 N.A. 87 53.7 N.A. 69.8 83.1 55.5 58.6 N.A. 39.3 47 N.A. 44.2
Protein Similarity: 100 99.7 73.8 96.7 N.A. 91.6 72.4 N.A. 77.6 88.8 70.9 75.2 N.A. 56.6 61.2 N.A. 62.8
P-Site Identity: 100 100 73.3 100 N.A. 86.6 73.3 N.A. 93.3 80 53.3 73.3 N.A. 13.3 6.6 N.A. 6.6
P-Site Similarity: 100 100 80 100 N.A. 100 80 N.A. 100 93.3 73.3 80 N.A. 13.3 20 N.A. 26.6
Percent
Protein Identity: N.A. 53.7 N.A. 30.1 N.A. N.A.
Protein Similarity: N.A. 72.4 N.A. 47 N.A. N.A.
P-Site Identity: N.A. 73.3 N.A. 0 N.A. N.A.
P-Site Similarity: N.A. 80 N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 0 74 14 0 0 7 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % D
% Glu: 34 0 7 0 67 0 0 7 67 0 7 7 0 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 74 % F
% Gly: 7 0 7 7 0 0 0 0 0 0 0 0 14 0 0 % G
% His: 0 0 14 0 0 0 0 0 0 0 20 0 0 0 0 % H
% Ile: 7 0 0 7 0 0 27 0 0 14 0 7 0 0 0 % I
% Lys: 0 0 7 0 14 0 14 7 7 7 0 0 74 14 7 % K
% Leu: 0 0 0 7 0 74 7 0 0 7 7 74 7 0 7 % L
% Met: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % M
% Asn: 0 7 54 7 0 0 7 0 0 0 0 0 0 7 7 % N
% Pro: 34 67 7 0 7 7 0 0 0 0 0 0 0 0 0 % P
% Gln: 7 0 0 0 0 0 7 0 0 0 0 0 0 0 7 % Q
% Arg: 0 0 7 0 0 0 14 0 0 0 7 0 0 0 0 % R
% Ser: 0 7 0 0 0 0 0 7 0 0 0 0 0 67 0 % S
% Thr: 0 0 0 0 0 7 0 0 7 0 47 0 7 0 0 % T
% Val: 7 0 0 0 0 14 20 0 7 67 7 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 74 7 7 0 14 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _