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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK1
All Species:
20
Human Site:
S408
Identified Species:
40
UniProt:
Q13464
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13464
NP_005397.1
1354
158175
S408
S
N
R
R
Y
L
S
S
A
N
P
N
D
N
R
Chimpanzee
Pan troglodytes
P61584
1003
117506
S229
K
S
I
S
Q
L
E
S
L
N
R
E
L
Q
E
Rhesus Macaque
Macaca mulatta
XP_001091134
1354
158171
S408
S
N
R
R
Y
L
S
S
A
N
P
N
D
N
R
Dog
Lupus familis
XP_537305
2025
232462
S1077
S
N
R
R
Y
L
S
S
A
N
P
N
D
N
R
Cat
Felis silvestris
Mouse
Mus musculus
P70335
1354
158152
S408
S
N
R
R
Y
L
P
S
A
N
A
S
E
N
R
Rat
Rattus norvegicus
Q63644
1369
159608
S408
S
N
R
R
Y
L
P
S
A
N
P
S
E
N
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
E404
A
D
K
K
R
N
L
E
N
D
V
N
S
L
K
Chicken
Gallus gallus
XP_419151
1358
158654
A410
R
R
Y
L
S
V
S
A
E
N
S
N
D
N
R
Frog
Xenopus laevis
NP_001154860
1372
159002
E410
R
E
N
L
L
L
S
E
S
S
Q
N
C
K
A
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
V411
E
N
Q
L
L
N
A
V
N
S
S
A
M
K
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
I456
G
D
D
T
L
D
T
I
S
S
P
Q
L
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
S381
S
N
K
L
L
F
W
S
C
D
C
I
V
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74
99.6
65.3
N.A.
96.5
94.8
N.A.
58.2
87.3
64.4
62.4
N.A.
24.3
N.A.
N.A.
47.5
Protein Similarity:
100
74
99.8
66.4
N.A.
98.7
97.4
N.A.
72.5
94.2
80.3
79.4
N.A.
45.8
N.A.
N.A.
66.2
P-Site Identity:
100
20
100
100
N.A.
73.3
80
N.A.
6.6
40
20
6.6
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
26.6
100
100
N.A.
86.6
93.3
N.A.
46.6
53.3
33.3
26.6
N.A.
33.3
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
9
9
42
0
9
9
0
9
9
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
9
0
9
0
0
% C
% Asp:
0
17
9
0
0
9
0
0
0
17
0
0
34
0
0
% D
% Glu:
9
9
0
0
0
0
9
17
9
0
0
9
17
0
17
% E
% Phe:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
0
0
0
9
0
0
0
9
0
0
9
% I
% Lys:
9
0
17
9
0
0
0
0
0
0
0
0
0
25
9
% K
% Leu:
0
0
0
34
34
59
9
0
9
0
0
0
17
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
59
9
0
0
17
0
0
17
59
0
50
0
50
9
% N
% Pro:
0
0
0
0
0
0
17
0
0
0
42
0
0
0
0
% P
% Gln:
0
0
9
0
9
0
0
0
0
0
9
9
0
9
0
% Q
% Arg:
17
9
42
42
9
0
0
0
0
0
9
0
0
0
50
% R
% Ser:
50
9
0
9
9
0
42
59
17
25
17
17
9
0
0
% S
% Thr:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
9
0
9
0
0
9
0
9
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
42
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _