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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ROCK1
All Species:
21.21
Human Site:
Y400
Identified Species:
42.42
UniProt:
Q13464
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13464
NP_005397.1
1354
158175
Y400
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
L
S
Chimpanzee
Pan troglodytes
P61584
1003
117506
S221
R
K
S
H
T
E
M
S
K
S
I
S
Q
L
E
Rhesus Macaque
Macaca mulatta
XP_001091134
1354
158171
Y400
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
L
S
Dog
Lupus familis
XP_537305
2025
232462
Y1069
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
L
S
Cat
Felis silvestris
Mouse
Mus musculus
P70335
1354
158152
Y400
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
L
P
Rat
Rattus norvegicus
Q63644
1369
159608
Y400
P
F
V
G
F
T
Y
Y
S
N
R
R
Y
L
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505615
1400
161955
E396
Y
Q
R
K
A
E
H
E
A
D
K
K
R
N
L
Chicken
Gallus gallus
XP_419151
1358
158654
N402
V
G
F
T
Y
Y
S
N
R
R
Y
L
S
V
S
Frog
Xenopus laevis
NP_001154860
1372
159002
Y402
P
F
V
G
F
T
Y
Y
R
E
N
L
L
L
S
Zebra Danio
Brachydanio rerio
NP_777288
1375
159755
K403
F
V
G
F
T
Y
F
K
E
N
Q
L
L
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9W1B0
1637
186706
F448
K
K
N
Q
S
S
G
F
G
D
D
T
L
D
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198244
1323
154677
K373
F
I
G
F
T
Y
N
K
S
N
K
L
L
F
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74
99.6
65.3
N.A.
96.5
94.8
N.A.
58.2
87.3
64.4
62.4
N.A.
24.3
N.A.
N.A.
47.5
Protein Similarity:
100
74
99.8
66.4
N.A.
98.7
97.4
N.A.
72.5
94.2
80.3
79.4
N.A.
45.8
N.A.
N.A.
66.2
P-Site Identity:
100
6.6
100
100
N.A.
93.3
93.3
N.A.
0
6.6
66.6
6.6
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
13.3
100
100
N.A.
93.3
93.3
N.A.
33.3
20
66.6
26.6
N.A.
26.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
9
0
0
0
9
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
17
9
0
0
9
0
% D
% Glu:
0
0
0
0
0
17
0
9
9
9
0
0
0
0
9
% E
% Phe:
17
50
9
17
50
0
9
9
0
0
0
0
0
9
0
% F
% Gly:
0
9
17
50
0
0
9
0
9
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
9
0
0
0
0
% I
% Lys:
9
17
0
9
0
0
0
17
9
0
17
9
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
34
34
59
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
9
9
0
59
9
0
0
17
0
% N
% Pro:
50
0
0
0
0
0
0
0
0
0
0
0
0
0
17
% P
% Gln:
0
9
0
9
0
0
0
0
0
0
9
0
9
0
0
% Q
% Arg:
9
0
9
0
0
0
0
0
17
9
42
42
9
0
0
% R
% Ser:
0
0
9
0
9
9
9
9
50
9
0
9
9
0
42
% S
% Thr:
0
0
0
9
25
50
0
0
0
0
0
9
0
0
9
% T
% Val:
9
9
50
0
0
0
0
0
0
0
0
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% W
% Tyr:
9
0
0
0
9
25
50
50
0
0
9
0
42
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _