KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
44.24
Human Site:
S503
Identified Species:
64.89
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S503
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S503
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S503
R
G
S
R
F
Q
P
S
T
V
E
M
V
D
G
Dog
Lupus familis
XP_546656
989
110956
S503
R
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
S503
Q
G
S
H
F
Q
P
S
T
V
E
M
V
D
G
Rat
Rattus norvegicus
XP_002742497
1001
111922
S501
Q
G
F
R
F
Q
P
S
T
V
E
M
V
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
T546
K
G
F
R
F
Q
P
T
T
V
E
M
V
E
G
Chicken
Gallus gallus
NP_001025807
1020
114626
T505
K
G
S
R
F
Q
P
T
T
V
E
M
V
D
G
Frog
Xenopus laevis
NP_001085699
1022
114003
T508
M
G
A
Q
F
Q
P
T
T
V
E
M
V
D
G
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
T501
P
N
T
T
F
Q
P
T
A
I
E
M
V
E
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
T496
N
G
Q
R
F
E
P
T
E
V
S
L
H
E
G
Honey Bee
Apis mellifera
XP_394050
958
109977
T470
E
G
Q
V
F
K
P
T
S
I
E
M
I
E
E
Nematode Worm
Caenorhab. elegans
O61660
759
85420
I309
V
E
L
E
K
L
G
I
S
K
L
R
M
S
A
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
Y229
L
G
F
V
V
E
R
Y
K
Q
V
E
A
F
I
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
K454
S
G
R
V
I
L
A
K
N
Y
L
D
V
Y
R
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
V476
F
E
S
W
G
G
S
V
I
P
V
Y
E
K
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
86.6
93.3
N.A.
100
86.6
N.A.
66.6
80
73.3
46.6
N.A.
33.3
33.3
0
6.6
P-Site Similarity:
100
100
93.3
100
N.A.
100
86.6
N.A.
86.6
93.3
86.6
73.3
N.A.
60
80
13.3
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
7
0
7
0
0
0
7
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
7
0
50
0
% D
% Glu:
7
13
0
7
0
13
0
0
7
0
69
7
7
25
7
% E
% Phe:
7
0
19
0
75
0
0
0
0
0
0
0
0
7
0
% F
% Gly:
0
82
0
0
7
7
7
0
0
0
0
0
0
0
75
% G
% His:
0
0
0
25
0
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
0
7
0
0
7
7
13
0
0
7
0
7
% I
% Lys:
13
0
0
0
7
7
0
7
7
7
0
0
0
7
0
% K
% Leu:
7
0
7
0
0
13
0
0
0
0
13
7
0
0
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
69
7
0
0
% M
% Asn:
7
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
75
0
0
7
0
0
0
0
0
% P
% Gln:
25
0
13
7
0
63
0
0
0
7
0
0
0
0
0
% Q
% Arg:
13
0
7
32
0
0
7
0
0
0
0
7
0
0
7
% R
% Ser:
7
0
44
0
0
0
7
38
13
0
7
0
0
7
0
% S
% Thr:
0
0
7
7
0
0
0
38
57
0
0
0
0
0
0
% T
% Val:
7
0
0
19
7
0
0
7
0
63
13
0
69
0
0
% V
% Trp:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
0
7
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _