KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
18.79
Human Site:
S753
Identified Species:
27.56
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S753
E
I
L
D
L
R
F
S
G
G
P
P
R
A
S
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S753
E
I
L
D
L
R
F
S
R
G
P
P
R
A
S
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S753
E
I
L
D
L
R
F
S
R
G
P
P
R
A
I
Dog
Lupus familis
XP_546656
989
110956
S753
E
I
L
D
L
R
F
S
R
G
P
P
R
A
S
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
P753
E
I
F
G
L
R
F
P
R
A
L
P
R
A
S
Rat
Rattus norvegicus
XP_002742497
1001
111922
S751
E
I
F
G
L
R
F
S
R
A
P
P
R
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
F796
E
I
L
D
L
R
Y
F
Q
G
P
P
R
A
L
Chicken
Gallus gallus
NP_001025807
1020
114626
S755
E
L
L
D
L
R
Y
S
H
R
S
S
Q
S
G
Frog
Xenopus laevis
NP_001085699
1022
114003
L758
E
I
L
D
L
K
Y
L
H
G
G
N
R
P
P
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
L752
E
V
L
N
L
K
Y
L
R
G
R
D
A
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
L755
R
T
T
F
N
I
N
L
D
S
V
K
K
V
G
Honey Bee
Apis mellifera
XP_394050
958
109977
G719
V
S
C
S
T
S
I
G
N
S
G
T
Y
S
F
Nematode Worm
Caenorhab. elegans
O61660
759
85420
V526
K
T
R
E
Y
I
G
V
R
P
D
G
K
L
I
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
A446
A
T
G
L
M
I
I
A
R
N
Y
L
D
V
Y
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
L674
V
W
L
P
G
P
V
L
E
A
T
I
T
N
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
C693
T
T
N
V
C
Q
S
C
G
P
G
P
V
Y
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
86.6
93.3
N.A.
60
73.3
N.A.
73.3
40
46.6
33.3
N.A.
0
0
0
0
P-Site Similarity:
100
93.3
86.6
93.3
N.A.
60
73.3
N.A.
80
66.6
60
60
N.A.
6.6
6.6
20
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
7
0
19
0
0
7
44
0
% A
% Cys:
0
0
7
0
7
0
0
7
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
44
0
0
0
0
7
0
7
7
7
0
0
% D
% Glu:
63
0
0
7
0
0
0
0
7
0
0
0
0
7
0
% E
% Phe:
0
0
13
7
0
0
38
7
0
0
0
0
0
0
7
% F
% Gly:
0
0
7
13
7
0
7
7
13
44
19
7
0
0
13
% G
% His:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% H
% Ile:
0
50
0
0
0
19
13
0
0
0
0
7
0
0
13
% I
% Lys:
7
0
0
0
0
13
0
0
0
0
0
7
13
0
7
% K
% Leu:
0
7
57
7
63
0
0
25
0
0
7
7
0
7
7
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
7
7
7
0
7
0
7
7
0
7
0
7
7
% N
% Pro:
0
0
0
7
0
7
0
7
0
13
38
50
0
7
7
% P
% Gln:
0
0
0
0
0
7
0
0
7
0
0
0
7
0
0
% Q
% Arg:
7
0
7
0
0
50
0
0
50
7
7
0
50
0
0
% R
% Ser:
0
7
0
7
0
7
7
38
0
13
7
7
0
13
38
% S
% Thr:
7
25
7
0
7
0
0
0
0
0
7
7
7
0
0
% T
% Val:
13
7
0
7
0
0
7
7
0
0
7
0
7
13
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
0
25
0
0
0
7
0
7
7
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _