Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 18.79
Human Site: S753 Identified Species: 27.56
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S753 E I L D L R F S G G P P R A S
Chimpanzee Pan troglodytes XP_511323 1001 112378 S753 E I L D L R F S R G P P R A S
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S753 E I L D L R F S R G P P R A I
Dog Lupus familis XP_546656 989 110956 S753 E I L D L R F S R G P P R A S
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 P753 E I F G L R F P R A L P R A S
Rat Rattus norvegicus XP_002742497 1001 111922 S751 E I F G L R F S R A P P R A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 F796 E I L D L R Y F Q G P P R A L
Chicken Gallus gallus NP_001025807 1020 114626 S755 E L L D L R Y S H R S S Q S G
Frog Xenopus laevis NP_001085699 1022 114003 L758 E I L D L K Y L H G G N R P P
Zebra Danio Brachydanio rerio XP_688695 998 112490 L752 E V L N L K Y L R G R D A E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 L755 R T T F N I N L D S V K K V G
Honey Bee Apis mellifera XP_394050 958 109977 G719 V S C S T S I G N S G T Y S F
Nematode Worm Caenorhab. elegans O61660 759 85420 V526 K T R E Y I G V R P D G K L I
Sea Urchin Strong. purpuratus XP_782119 679 77025 A446 A T G L M I I A R N Y L D V Y
Poplar Tree Populus trichocarpa XP_002307047 910 102138 L674 V W L P G P V L E A T I T N N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 C693 T T N V C Q S C G P G P V Y K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 93.3 86.6 93.3 N.A. 60 73.3 N.A. 73.3 40 46.6 33.3 N.A. 0 0 0 0
P-Site Similarity: 100 93.3 86.6 93.3 N.A. 60 73.3 N.A. 80 66.6 60 60 N.A. 6.6 6.6 20 13.3
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 0 0 7 0 19 0 0 7 44 0 % A
% Cys: 0 0 7 0 7 0 0 7 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 44 0 0 0 0 7 0 7 7 7 0 0 % D
% Glu: 63 0 0 7 0 0 0 0 7 0 0 0 0 7 0 % E
% Phe: 0 0 13 7 0 0 38 7 0 0 0 0 0 0 7 % F
% Gly: 0 0 7 13 7 0 7 7 13 44 19 7 0 0 13 % G
% His: 0 0 0 0 0 0 0 0 13 0 0 0 0 0 0 % H
% Ile: 0 50 0 0 0 19 13 0 0 0 0 7 0 0 13 % I
% Lys: 7 0 0 0 0 13 0 0 0 0 0 7 13 0 7 % K
% Leu: 0 7 57 7 63 0 0 25 0 0 7 7 0 7 7 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 7 7 7 0 7 0 7 7 0 7 0 7 7 % N
% Pro: 0 0 0 7 0 7 0 7 0 13 38 50 0 7 7 % P
% Gln: 0 0 0 0 0 7 0 0 7 0 0 0 7 0 0 % Q
% Arg: 7 0 7 0 0 50 0 0 50 7 7 0 50 0 0 % R
% Ser: 0 7 0 7 0 7 7 38 0 13 7 7 0 13 38 % S
% Thr: 7 25 7 0 7 0 0 0 0 0 7 7 7 0 0 % T
% Val: 13 7 0 7 0 0 7 7 0 0 7 0 7 13 0 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 0 25 0 0 0 7 0 7 7 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _