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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
15.45
Human Site:
S760
Identified Species:
22.67
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S760
S
G
G
P
P
R
A
S
Q
P
S
G
R
L
Q
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S760
S
R
G
P
P
R
A
S
Q
P
S
G
R
L
Q
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
I760
S
R
G
P
P
R
A
I
Q
P
S
G
H
L
Q
Dog
Lupus familis
XP_546656
989
110956
S760
S
R
G
P
P
R
A
S
Q
P
A
S
Q
P
S
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
S760
P
R
A
L
P
R
A
S
Q
P
S
G
H
L
Q
Rat
Rattus norvegicus
XP_002742497
1001
111922
S758
S
R
A
P
P
R
A
S
Q
P
S
G
H
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
L803
F
Q
G
P
P
R
A
L
H
P
A
S
H
V
Q
Chicken
Gallus gallus
NP_001025807
1020
114626
G762
S
H
R
S
S
Q
S
G
Q
S
A
S
Q
Q
A
Frog
Xenopus laevis
NP_001085699
1022
114003
P765
L
H
G
G
N
R
P
P
Q
A
A
P
R
E
S
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
S759
L
R
G
R
D
A
E
S
A
P
Q
A
N
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
G762
L
D
S
V
K
K
V
G
G
I
V
G
E
V
R
Honey Bee
Apis mellifera
XP_394050
958
109977
F726
G
N
S
G
T
Y
S
F
L
N
I
R
N
E
T
Nematode Worm
Caenorhab. elegans
O61660
759
85420
I533
V
R
P
D
G
K
L
I
P
S
F
L
G
L
A
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
Y453
A
R
N
Y
L
D
V
Y
P
Y
E
K
W
N
A
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
N681
L
E
A
T
I
T
N
N
I
C
N
S
C
T
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
K700
C
G
P
G
P
V
Y
K
I
L
F
K
F
R
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
80
60
N.A.
66.6
80
N.A.
46.6
13.3
26.6
20
N.A.
6.6
0
6.6
0
P-Site Similarity:
100
93.3
80
73.3
N.A.
66.6
80
N.A.
60
40
33.3
20
N.A.
26.6
6.6
13.3
6.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
19
0
0
7
44
0
7
7
25
7
0
0
19
% A
% Cys:
7
0
0
0
0
0
0
0
0
7
0
0
7
0
0
% C
% Asp:
0
7
0
7
7
7
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
7
0
0
0
0
7
0
0
0
7
0
7
13
0
% E
% Phe:
7
0
0
0
0
0
0
7
0
0
13
0
7
0
0
% F
% Gly:
7
13
44
19
7
0
0
13
7
0
0
38
7
0
0
% G
% His:
0
13
0
0
0
0
0
0
7
0
0
0
25
0
0
% H
% Ile:
0
0
0
0
7
0
0
13
13
7
7
0
0
0
0
% I
% Lys:
0
0
0
0
7
13
0
7
0
0
0
13
0
0
0
% K
% Leu:
25
0
0
7
7
0
7
7
7
7
0
7
0
38
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
7
0
7
0
7
7
0
7
7
0
13
13
0
% N
% Pro:
7
0
13
38
50
0
7
7
13
50
0
7
0
7
7
% P
% Gln:
0
7
0
0
0
7
0
0
50
0
7
0
13
7
44
% Q
% Arg:
0
50
7
7
0
50
0
0
0
0
0
7
19
7
7
% R
% Ser:
38
0
13
7
7
0
13
38
0
13
32
25
0
0
19
% S
% Thr:
0
0
0
7
7
7
0
0
0
0
0
0
0
7
7
% T
% Val:
7
0
0
7
0
7
13
0
0
0
7
0
0
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% W
% Tyr:
0
0
0
7
0
7
7
7
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _