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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 17.58
Human Site: S778 Identified Species: 25.78
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S778 S L N R M D N S Q H P Q P A D
Chimpanzee Pan troglodytes XP_511323 1001 112378 S778 S L N R M D N S Q H P Q P A D
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S778 S L N R M D N S Q H P Q P A D
Dog Lupus familis XP_546656 989 110956 R778 Q A S Q S Q N R T D S A P R M
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 S778 A L N R M D S S Q H N L S Q P
Rat Rattus norvegicus XP_002742497 1001 111922 S776 A L N R M D S S Q R S L S Q P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 R821 S L N R M G S R Y N H Q P R P
Chicken Gallus gallus NP_001025807 1020 114626 R780 Q V N N S F N R A N S E N R R
Frog Xenopus laevis NP_001085699 1022 114003 R783 Q V N Q T S N R M G N S G D G
Zebra Danio Brachydanio rerio XP_688695 998 112490 T777 S Q H H I H R T S S A P P P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 G780 G G P G P G P G G G G S G R G
Honey Bee Apis mellifera XP_394050 958 109977 F744 E C N I S T E F I R N Q N I N
Nematode Worm Caenorhab. elegans O61660 759 85420 A551 G Y D D M G F A M S K P D L R
Sea Urchin Strong. purpuratus XP_782119 679 77025 T471 P V Y D R G Q T F E P T S L E
Poplar Tree Populus trichocarpa XP_002307047 910 102138 R699 Y L I Q F K F R Q L E I P P G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 H718 P P G F D V N H L G C V G G C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 13.3 N.A. 53.3 46.6 N.A. 46.6 13.3 13.3 13.3 N.A. 0 13.3 6.6 6.6
P-Site Similarity: 100 100 100 26.6 N.A. 66.6 60 N.A. 60 33.3 26.6 33.3 N.A. 0 20 20 26.6
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 20 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 7 0 0 0 0 0 7 7 0 7 7 0 19 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 7 0 0 0 7 % C
% Asp: 0 0 7 13 7 32 0 0 0 7 0 0 7 7 19 % D
% Glu: 7 0 0 0 0 0 7 0 0 7 7 7 0 0 7 % E
% Phe: 0 0 0 7 7 7 13 7 7 0 0 0 0 0 0 % F
% Gly: 13 7 7 7 0 25 0 7 7 19 7 0 19 7 19 % G
% His: 0 0 7 7 0 7 0 7 0 25 7 0 0 0 0 % H
% Ile: 0 0 7 7 7 0 0 0 7 0 0 7 0 7 0 % I
% Lys: 0 0 0 0 0 7 0 0 0 0 7 0 0 0 0 % K
% Leu: 0 44 0 0 0 0 0 0 7 7 0 13 0 13 0 % L
% Met: 0 0 0 0 44 0 0 0 13 0 0 0 0 0 7 % M
% Asn: 0 0 57 7 0 0 44 0 0 13 19 0 13 0 7 % N
% Pro: 13 7 7 0 7 0 7 0 0 0 25 13 44 13 19 % P
% Gln: 19 7 0 19 0 7 7 0 38 0 0 32 0 13 0 % Q
% Arg: 0 0 0 38 7 0 7 32 0 13 0 0 0 25 13 % R
% Ser: 32 0 7 0 19 7 19 32 7 13 19 13 19 0 7 % S
% Thr: 0 0 0 0 7 7 0 13 7 0 0 7 0 0 0 % T
% Val: 0 19 0 0 0 7 0 0 0 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 7 7 0 0 0 0 0 7 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _