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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 13.94
Human Site: S870 Identified Species: 20.44
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S870 A Y R P L G A S L G C P P G P
Chimpanzee Pan troglodytes XP_511323 1001 112378 S870 A Y R P L G A S L G C P P G P
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S870 A Y R P L G G S L G R P P G P
Dog Lupus familis XP_546656 989 110956 D867 G H P P A M G D R R G G F G R
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 S872 A S G P P G S S V G C P S S V
Rat Rattus norvegicus XP_002742497 1001 111922 S870 V S R P P G N S V G C P S G F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 P916 T A V I P A P P P A G G S R E
Chicken Gallus gallus NP_001025807 1020 114626 F882 G S A P P R A F G A R G P A N
Frog Xenopus laevis NP_001085699 1022 114003 N884 P S T G R P S N A F N N S R A
Zebra Danio Brachydanio rerio XP_688695 998 112490 Q872 G P L S Q N V Q P P R P S N G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 D935 S M V P L D D D I A A A F A A
Honey Bee Apis mellifera XP_394050 958 109977 N835 N N T S K D S N L V N T I T E
Nematode Worm Caenorhab. elegans O61660 759 85420 P639 G G G G G G G P T G P P A P P
Sea Urchin Strong. purpuratus XP_782119 679 77025 E559 S K P N L R A E L E S D L K R
Poplar Tree Populus trichocarpa XP_002307047 910 102138 N788 H V Q S H G M N Q Q N G E S S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 C806 N D E S T V S C N T C G S Q C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 86.6 13.3 N.A. 46.6 53.3 N.A. 0 20 0 6.6 N.A. 13.3 6.6 26.6 20
P-Site Similarity: 100 100 86.6 20 N.A. 60 60 N.A. 0 20 13.3 6.6 N.A. 26.6 20 26.6 26.6
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 25 7 7 0 7 7 25 0 7 19 7 7 7 13 13 % A
% Cys: 0 0 0 0 0 0 0 7 0 0 32 0 0 0 7 % C
% Asp: 0 7 0 0 0 13 7 13 0 0 0 7 0 0 0 % D
% Glu: 0 0 7 0 0 0 0 7 0 7 0 0 7 0 13 % E
% Phe: 0 0 0 0 0 0 0 7 0 7 0 0 13 0 7 % F
% Gly: 25 7 13 13 7 44 19 0 7 38 13 32 0 32 7 % G
% His: 7 7 0 0 7 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 0 0 0 0 7 0 0 0 7 0 0 % I
% Lys: 0 7 0 0 7 0 0 0 0 0 0 0 0 7 0 % K
% Leu: 0 0 7 0 32 0 0 0 32 0 0 0 7 0 0 % L
% Met: 0 7 0 0 0 7 7 0 0 0 0 0 0 0 0 % M
% Asn: 13 7 0 7 0 7 7 19 7 0 19 7 0 7 7 % N
% Pro: 7 7 13 50 25 7 7 13 13 7 7 44 25 7 25 % P
% Gln: 0 0 7 0 7 0 0 7 7 7 0 0 0 7 0 % Q
% Arg: 0 0 25 0 7 13 0 0 7 7 19 0 0 13 13 % R
% Ser: 13 25 0 25 0 0 25 32 0 0 7 0 38 13 7 % S
% Thr: 7 0 13 0 7 0 0 0 7 7 0 7 0 7 0 % T
% Val: 7 7 13 0 0 7 7 0 13 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 19 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _