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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
13.94
Human Site:
S870
Identified Species:
20.44
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S870
A
Y
R
P
L
G
A
S
L
G
C
P
P
G
P
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S870
A
Y
R
P
L
G
A
S
L
G
C
P
P
G
P
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S870
A
Y
R
P
L
G
G
S
L
G
R
P
P
G
P
Dog
Lupus familis
XP_546656
989
110956
D867
G
H
P
P
A
M
G
D
R
R
G
G
F
G
R
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
S872
A
S
G
P
P
G
S
S
V
G
C
P
S
S
V
Rat
Rattus norvegicus
XP_002742497
1001
111922
S870
V
S
R
P
P
G
N
S
V
G
C
P
S
G
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
P916
T
A
V
I
P
A
P
P
P
A
G
G
S
R
E
Chicken
Gallus gallus
NP_001025807
1020
114626
F882
G
S
A
P
P
R
A
F
G
A
R
G
P
A
N
Frog
Xenopus laevis
NP_001085699
1022
114003
N884
P
S
T
G
R
P
S
N
A
F
N
N
S
R
A
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
Q872
G
P
L
S
Q
N
V
Q
P
P
R
P
S
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
D935
S
M
V
P
L
D
D
D
I
A
A
A
F
A
A
Honey Bee
Apis mellifera
XP_394050
958
109977
N835
N
N
T
S
K
D
S
N
L
V
N
T
I
T
E
Nematode Worm
Caenorhab. elegans
O61660
759
85420
P639
G
G
G
G
G
G
G
P
T
G
P
P
A
P
P
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
E559
S
K
P
N
L
R
A
E
L
E
S
D
L
K
R
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
N788
H
V
Q
S
H
G
M
N
Q
Q
N
G
E
S
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
C806
N
D
E
S
T
V
S
C
N
T
C
G
S
Q
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
86.6
13.3
N.A.
46.6
53.3
N.A.
0
20
0
6.6
N.A.
13.3
6.6
26.6
20
P-Site Similarity:
100
100
86.6
20
N.A.
60
60
N.A.
0
20
13.3
6.6
N.A.
26.6
20
26.6
26.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
7
7
0
7
7
25
0
7
19
7
7
7
13
13
% A
% Cys:
0
0
0
0
0
0
0
7
0
0
32
0
0
0
7
% C
% Asp:
0
7
0
0
0
13
7
13
0
0
0
7
0
0
0
% D
% Glu:
0
0
7
0
0
0
0
7
0
7
0
0
7
0
13
% E
% Phe:
0
0
0
0
0
0
0
7
0
7
0
0
13
0
7
% F
% Gly:
25
7
13
13
7
44
19
0
7
38
13
32
0
32
7
% G
% His:
7
7
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
7
0
0
0
7
0
0
% I
% Lys:
0
7
0
0
7
0
0
0
0
0
0
0
0
7
0
% K
% Leu:
0
0
7
0
32
0
0
0
32
0
0
0
7
0
0
% L
% Met:
0
7
0
0
0
7
7
0
0
0
0
0
0
0
0
% M
% Asn:
13
7
0
7
0
7
7
19
7
0
19
7
0
7
7
% N
% Pro:
7
7
13
50
25
7
7
13
13
7
7
44
25
7
25
% P
% Gln:
0
0
7
0
7
0
0
7
7
7
0
0
0
7
0
% Q
% Arg:
0
0
25
0
7
13
0
0
7
7
19
0
0
13
13
% R
% Ser:
13
25
0
25
0
0
25
32
0
0
7
0
38
13
7
% S
% Thr:
7
0
13
0
7
0
0
0
7
7
0
7
0
7
0
% T
% Val:
7
7
13
0
0
7
7
0
13
7
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
19
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _