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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
20.61
Human Site:
S964
Identified Species:
30.22
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S964
T
L
E
S
E
A
R
S
K
R
P
R
A
S
S
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S964
T
L
G
S
E
A
R
S
K
R
P
R
A
S
S
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S964
I
L
G
L
E
A
R
S
K
R
P
R
A
S
S
Dog
Lupus familis
XP_546656
989
110956
S952
T
Q
G
P
E
A
R
S
K
R
A
R
A
S
S
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
S966
A
Q
R
P
E
A
A
S
K
R
P
R
A
G
S
Rat
Rattus norvegicus
XP_002742497
1001
111922
S964
A
Q
R
P
E
A
A
S
K
R
Q
R
A
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
S1005
Q
R
G
P
R
G
R
S
K
R
P
G
A
N
S
Chicken
Gallus gallus
NP_001025807
1020
114626
S983
E
Y
S
R
E
L
G
S
K
A
K
R
P
S
N
Frog
Xenopus laevis
NP_001085699
1022
114003
K985
G
A
Q
R
N
S
G
K
K
N
K
R
S
E
N
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
G961
G
N
G
G
K
P
S
G
N
K
K
A
S
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
N1209
S
W
G
S
A
N
R
N
P
P
G
R
S
Q
P
Honey Bee
Apis mellifera
XP_394050
958
109977
R919
K
K
R
F
K
K
D
R
S
E
Q
L
Q
N
L
Nematode Worm
Caenorhab. elegans
O61660
759
85420
R723
C
Q
C
P
E
P
M
R
A
V
T
K
V
V
Q
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
K643
P
M
T
L
K
E
R
K
A
G
G
W
M
V
S
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
A874
G
V
Q
N
A
G
R
A
A
D
V
T
F
V
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
V890
R
G
S
G
T
S
F
V
S
A
T
G
E
P
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
93.3
80
73.3
N.A.
60
53.3
N.A.
46.6
33.3
13.3
0
N.A.
20
0
6.6
13.3
P-Site Similarity:
100
93.3
80
73.3
N.A.
60
53.3
N.A.
53.3
40
40
33.3
N.A.
40
13.3
13.3
26.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
7
0
0
13
38
13
7
19
13
7
7
44
0
0
% A
% Cys:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
0
7
0
0
0
0
0
% D
% Glu:
7
0
7
0
50
7
0
0
0
7
0
0
7
7
0
% E
% Phe:
0
0
0
7
0
0
7
0
0
0
0
0
7
0
0
% F
% Gly:
19
7
38
13
0
13
13
7
0
7
13
13
0
13
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
7
7
0
0
19
7
0
13
57
7
19
7
0
0
0
% K
% Leu:
0
19
0
13
0
7
0
0
0
0
0
7
0
0
7
% L
% Met:
0
7
0
0
0
0
7
0
0
0
0
0
7
0
0
% M
% Asn:
0
7
0
7
7
7
0
7
7
7
0
0
0
13
13
% N
% Pro:
7
0
0
32
0
13
0
0
7
7
32
0
7
7
7
% P
% Gln:
7
25
13
0
0
0
0
0
0
0
13
0
7
7
7
% Q
% Arg:
7
7
19
13
7
0
50
13
0
44
0
57
0
0
0
% R
% Ser:
7
0
13
19
0
13
7
50
13
0
0
0
19
32
57
% S
% Thr:
19
0
7
0
7
0
0
0
0
0
13
7
0
7
7
% T
% Val:
0
7
0
0
0
0
0
7
0
7
7
0
7
19
7
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _