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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 20.61
Human Site: S964 Identified Species: 30.22
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S964 T L E S E A R S K R P R A S S
Chimpanzee Pan troglodytes XP_511323 1001 112378 S964 T L G S E A R S K R P R A S S
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S964 I L G L E A R S K R P R A S S
Dog Lupus familis XP_546656 989 110956 S952 T Q G P E A R S K R A R A S S
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 S966 A Q R P E A A S K R P R A G S
Rat Rattus norvegicus XP_002742497 1001 111922 S964 A Q R P E A A S K R Q R A G S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 S1005 Q R G P R G R S K R P G A N S
Chicken Gallus gallus NP_001025807 1020 114626 S983 E Y S R E L G S K A K R P S N
Frog Xenopus laevis NP_001085699 1022 114003 K985 G A Q R N S G K K N K R S E N
Zebra Danio Brachydanio rerio XP_688695 998 112490 G961 G N G G K P S G N K K A S T T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 N1209 S W G S A N R N P P G R S Q P
Honey Bee Apis mellifera XP_394050 958 109977 R919 K K R F K K D R S E Q L Q N L
Nematode Worm Caenorhab. elegans O61660 759 85420 R723 C Q C P E P M R A V T K V V Q
Sea Urchin Strong. purpuratus XP_782119 679 77025 K643 P M T L K E R K A G G W M V S
Poplar Tree Populus trichocarpa XP_002307047 910 102138 A874 G V Q N A G R A A D V T F V S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 V890 R G S G T S F V S A T G E P V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 93.3 80 73.3 N.A. 60 53.3 N.A. 46.6 33.3 13.3 0 N.A. 20 0 6.6 13.3
P-Site Similarity: 100 93.3 80 73.3 N.A. 60 53.3 N.A. 53.3 40 40 33.3 N.A. 40 13.3 13.3 26.6
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 40 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 13 7 0 0 13 38 13 7 19 13 7 7 44 0 0 % A
% Cys: 7 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % D
% Glu: 7 0 7 0 50 7 0 0 0 7 0 0 7 7 0 % E
% Phe: 0 0 0 7 0 0 7 0 0 0 0 0 7 0 0 % F
% Gly: 19 7 38 13 0 13 13 7 0 7 13 13 0 13 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 7 7 0 0 19 7 0 13 57 7 19 7 0 0 0 % K
% Leu: 0 19 0 13 0 7 0 0 0 0 0 7 0 0 7 % L
% Met: 0 7 0 0 0 0 7 0 0 0 0 0 7 0 0 % M
% Asn: 0 7 0 7 7 7 0 7 7 7 0 0 0 13 13 % N
% Pro: 7 0 0 32 0 13 0 0 7 7 32 0 7 7 7 % P
% Gln: 7 25 13 0 0 0 0 0 0 0 13 0 7 7 7 % Q
% Arg: 7 7 19 13 7 0 50 13 0 44 0 57 0 0 0 % R
% Ser: 7 0 13 19 0 13 7 50 13 0 0 0 19 32 57 % S
% Thr: 19 0 7 0 7 0 0 0 0 0 13 7 0 7 7 % T
% Val: 0 7 0 0 0 0 0 7 0 7 7 0 7 19 7 % V
% Trp: 0 7 0 0 0 0 0 0 0 0 0 7 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _