Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 26.06
Human Site: S971 Identified Species: 38.22
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S971 S K R P R A S S S D M G S T A
Chimpanzee Pan troglodytes XP_511323 1001 112378 S971 S K R P R A S S S D M G S T A
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S971 S K R P R A S S S D T G S T A
Dog Lupus familis XP_546656 989 110956 S959 S K R A R A S S A D M G S T P
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 S973 S K R P R A G S S D A G S T V
Rat Rattus norvegicus XP_002742497 1001 111922 S971 S K R Q R A G S L D A G S T V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 S1012 S K R P G A N S T A T R P T S
Chicken Gallus gallus NP_001025807 1020 114626 N990 S K A K R P S N L S H G A T A
Frog Xenopus laevis NP_001085699 1022 114003 N992 K K N K R S E N S F S G P T A
Zebra Danio Brachydanio rerio XP_688695 998 112490 T968 G N K K A S T T S V K P P T A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 P1216 N P P G R S Q P T A I T S D G
Honey Bee Apis mellifera XP_394050 958 109977 L926 R S E Q L Q N L Q K R P R V V
Nematode Worm Caenorhab. elegans O61660 759 85420 Q730 R A V T K V V Q K E G P N K G
Sea Urchin Strong. purpuratus XP_782119 679 77025 S650 K A G G W M V S C M G Y P G C
Poplar Tree Populus trichocarpa XP_002307047 910 102138 S881 A A D V T F V S A T G E P I S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 V897 V S A T G E P V S G I R C F S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 93.3 80 N.A. 80 66.6 N.A. 46.6 46.6 40 20 N.A. 13.3 0 0 6.6
P-Site Similarity: 100 100 93.3 86.6 N.A. 80 66.6 N.A. 66.6 60 53.3 46.6 N.A. 40 6.6 20 6.6
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 19 13 7 7 44 0 0 13 13 13 0 7 0 38 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 7 0 7 % C
% Asp: 0 0 7 0 0 0 0 0 0 38 0 0 0 7 0 % D
% Glu: 0 0 7 0 0 7 7 0 0 7 0 7 0 0 0 % E
% Phe: 0 0 0 0 0 7 0 0 0 7 0 0 0 7 0 % F
% Gly: 7 0 7 13 13 0 13 0 0 7 19 50 0 7 13 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 13 0 0 7 0 % I
% Lys: 13 57 7 19 7 0 0 0 7 7 7 0 0 7 0 % K
% Leu: 0 0 0 0 7 0 0 7 13 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 7 0 0 0 7 19 0 0 0 0 % M
% Asn: 7 7 7 0 0 0 13 13 0 0 0 0 7 0 0 % N
% Pro: 0 7 7 32 0 7 7 7 0 0 0 19 32 0 7 % P
% Gln: 0 0 0 13 0 7 7 7 7 0 0 0 0 0 0 % Q
% Arg: 13 0 44 0 57 0 0 0 0 0 7 13 7 0 0 % R
% Ser: 50 13 0 0 0 19 32 57 44 7 7 0 44 0 19 % S
% Thr: 0 0 0 13 7 0 7 7 13 7 13 7 0 63 0 % T
% Val: 7 0 7 7 0 7 19 7 0 7 0 0 0 7 19 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _