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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
22.12
Human Site:
S976
Identified Species:
32.44
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
S976
A
S
S
S
D
M
G
S
T
A
K
K
P
R
K
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
S976
A
S
S
S
D
M
G
S
T
A
K
K
P
R
K
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
S976
A
S
S
S
D
T
G
S
T
A
K
K
P
R
K
Dog
Lupus familis
XP_546656
989
110956
S964
A
S
S
A
D
M
G
S
T
P
K
K
P
R
K
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
S978
A
G
S
S
D
A
G
S
T
V
K
K
P
R
K
Rat
Rattus norvegicus
XP_002742497
1001
111922
S976
A
G
S
L
D
A
G
S
T
V
K
K
P
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
P1017
A
N
S
T
A
T
R
P
T
S
K
R
P
R
T
Chicken
Gallus gallus
NP_001025807
1020
114626
A995
P
S
N
L
S
H
G
A
T
A
K
K
P
R
T
Frog
Xenopus laevis
NP_001085699
1022
114003
P997
S
E
N
S
F
S
G
P
T
A
K
K
P
R
S
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
P973
S
T
T
S
V
K
P
P
T
A
K
R
Q
R
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
S1221
S
Q
P
T
A
I
T
S
D
G
P
K
T
R
R
Honey Bee
Apis mellifera
XP_394050
958
109977
R931
Q
N
L
Q
K
R
P
R
V
V
T
G
K
R
K
Nematode Worm
Caenorhab. elegans
O61660
759
85420
N735
V
V
Q
K
E
G
P
N
K
G
K
K
F
Y
T
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
P655
M
V
S
C
M
G
Y
P
G
C
K
A
A
V
W
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
P886
F
V
S
A
T
G
E
P
I
S
G
R
R
C
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
C902
E
P
V
S
G
I
R
C
F
S
C
G
D
P
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
93.3
86.6
N.A.
80
73.3
N.A.
40
53.3
53.3
33.3
N.A.
20
13.3
13.3
13.3
P-Site Similarity:
100
100
93.3
93.3
N.A.
80
73.3
N.A.
66.6
66.6
66.6
60
N.A.
46.6
20
26.6
13.3
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
44
0
0
13
13
13
0
7
0
38
0
7
7
0
0
% A
% Cys:
0
0
0
7
0
0
0
7
0
7
7
0
0
7
0
% C
% Asp:
0
0
0
0
38
0
0
0
7
0
0
0
7
0
0
% D
% Glu:
7
7
0
0
7
0
7
0
0
0
0
0
0
0
0
% E
% Phe:
7
0
0
0
7
0
0
0
7
0
0
0
7
0
7
% F
% Gly:
0
13
0
0
7
19
50
0
7
13
7
13
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
13
0
0
7
0
0
0
0
0
0
% I
% Lys:
0
0
0
7
7
7
0
0
7
0
75
63
7
0
44
% K
% Leu:
0
0
7
13
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
7
0
0
0
7
19
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
13
13
0
0
0
0
7
0
0
0
0
0
0
0
% N
% Pro:
7
7
7
0
0
0
19
32
0
7
7
0
57
7
0
% P
% Gln:
7
7
7
7
0
0
0
0
0
0
0
0
7
0
0
% Q
% Arg:
0
0
0
0
0
7
13
7
0
0
0
19
7
75
7
% R
% Ser:
19
32
57
44
7
7
0
44
0
19
0
0
0
0
13
% S
% Thr:
0
7
7
13
7
13
7
0
63
0
7
0
7
0
25
% T
% Val:
7
19
7
0
7
0
0
0
7
19
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _