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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 22.12
Human Site: S976 Identified Species: 32.44
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 S976 A S S S D M G S T A K K P R K
Chimpanzee Pan troglodytes XP_511323 1001 112378 S976 A S S S D M G S T A K K P R K
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 S976 A S S S D T G S T A K K P R K
Dog Lupus familis XP_546656 989 110956 S964 A S S A D M G S T P K K P R K
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 S978 A G S S D A G S T V K K P R K
Rat Rattus norvegicus XP_002742497 1001 111922 S976 A G S L D A G S T V K K P R K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 P1017 A N S T A T R P T S K R P R T
Chicken Gallus gallus NP_001025807 1020 114626 A995 P S N L S H G A T A K K P R T
Frog Xenopus laevis NP_001085699 1022 114003 P997 S E N S F S G P T A K K P R S
Zebra Danio Brachydanio rerio XP_688695 998 112490 P973 S T T S V K P P T A K R Q R T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 S1221 S Q P T A I T S D G P K T R R
Honey Bee Apis mellifera XP_394050 958 109977 R931 Q N L Q K R P R V V T G K R K
Nematode Worm Caenorhab. elegans O61660 759 85420 N735 V V Q K E G P N K G K K F Y T
Sea Urchin Strong. purpuratus XP_782119 679 77025 P655 M V S C M G Y P G C K A A V W
Poplar Tree Populus trichocarpa XP_002307047 910 102138 P886 F V S A T G E P I S G R R C F
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 C902 E P V S G I R C F S C G D P S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 93.3 86.6 N.A. 80 73.3 N.A. 40 53.3 53.3 33.3 N.A. 20 13.3 13.3 13.3
P-Site Similarity: 100 100 93.3 93.3 N.A. 80 73.3 N.A. 66.6 66.6 66.6 60 N.A. 46.6 20 26.6 13.3
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 44 0 0 13 13 13 0 7 0 38 0 7 7 0 0 % A
% Cys: 0 0 0 7 0 0 0 7 0 7 7 0 0 7 0 % C
% Asp: 0 0 0 0 38 0 0 0 7 0 0 0 7 0 0 % D
% Glu: 7 7 0 0 7 0 7 0 0 0 0 0 0 0 0 % E
% Phe: 7 0 0 0 7 0 0 0 7 0 0 0 7 0 7 % F
% Gly: 0 13 0 0 7 19 50 0 7 13 7 13 0 0 0 % G
% His: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 13 0 0 7 0 0 0 0 0 0 % I
% Lys: 0 0 0 7 7 7 0 0 7 0 75 63 7 0 44 % K
% Leu: 0 0 7 13 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 7 0 0 0 7 19 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 13 13 0 0 0 0 7 0 0 0 0 0 0 0 % N
% Pro: 7 7 7 0 0 0 19 32 0 7 7 0 57 7 0 % P
% Gln: 7 7 7 7 0 0 0 0 0 0 0 0 7 0 0 % Q
% Arg: 0 0 0 0 0 7 13 7 0 0 0 19 7 75 7 % R
% Ser: 19 32 57 44 7 7 0 44 0 19 0 0 0 0 13 % S
% Thr: 0 7 7 13 7 13 7 0 63 0 7 0 7 0 25 % T
% Val: 7 19 7 0 7 0 0 0 7 19 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _