Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 47.88
Human Site: T512 Identified Species: 70.22
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 T512 V E M V D G E T S P P K L L T
Chimpanzee Pan troglodytes XP_511323 1001 112378 T512 V E M V D G E T S P P K L L T
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 T512 V E M V D G E T S P P K L L T
Dog Lupus familis XP_546656 989 110956 T512 V E M V D G E T S P P Q L L T
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 T512 V E M V D G E T S P P Q L L T
Rat Rattus norvegicus XP_002742497 1001 111922 T510 V E M V D G E T S P P Q L L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 T555 V E M V E G E T S P P Q L L T
Chicken Gallus gallus NP_001025807 1020 114626 T514 V E M V D G E T S P P L L L T
Frog Xenopus laevis NP_001085699 1022 114003 T517 V E M V D G E T S P P Q L L T
Zebra Danio Brachydanio rerio XP_688695 998 112490 T510 I E M V E G Q T S P P Q L L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 T505 V S L H E G A T T A P P L L T
Honey Bee Apis mellifera XP_394050 958 109977 T479 I E M I E E K T S P P Q L L T
Nematode Worm Caenorhab. elegans O61660 759 85420 Q318 K L R M S A K Q T M Q V A E K
Sea Urchin Strong. purpuratus XP_782119 679 77025 E238 Q V E A F I P E T F Y K I K V
Poplar Tree Populus trichocarpa XP_002307047 910 102138 E463 Y L D V Y R F E S W G D S M I
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 Q485 P V Y E K G Q Q F I P T T L T
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 86.6 93.3 93.3 73.3 N.A. 46.6 60 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 93.3 100 100 N.A. 66.6 93.3 20 20
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 33.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 7 7 0 0 7 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 50 0 0 0 0 0 0 7 0 0 0 % D
% Glu: 0 69 7 7 25 7 57 13 0 0 0 0 0 7 0 % E
% Phe: 0 0 0 0 7 0 7 0 7 7 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 75 0 0 0 0 7 0 0 0 0 % G
% His: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 13 0 0 7 0 7 0 0 0 7 0 0 7 0 7 % I
% Lys: 7 0 0 0 7 0 13 0 0 0 0 25 0 7 7 % K
% Leu: 0 13 7 0 0 0 0 0 0 0 0 7 75 82 0 % L
% Met: 0 0 69 7 0 0 0 0 0 7 0 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 7 0 0 0 0 0 7 0 0 69 82 7 0 0 0 % P
% Gln: 7 0 0 0 0 0 13 13 0 0 7 44 0 0 0 % Q
% Arg: 0 0 7 0 0 7 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 0 0 7 0 0 0 75 0 0 0 7 0 0 % S
% Thr: 0 0 0 0 0 0 0 75 19 0 0 7 7 0 82 % T
% Val: 63 13 0 69 0 0 0 0 0 0 0 7 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 7 0 7 0 7 0 0 0 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _