KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
36.06
Human Site:
T669
Identified Species:
52.89
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T669
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T669
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
T669
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Dog
Lupus familis
XP_546656
989
110956
T669
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
T669
N
K
D
M
V
L
K
T
K
K
S
G
G
F
Y
Rat
Rattus norvegicus
XP_002742497
1001
111922
T667
N
K
D
M
V
L
K
T
K
K
S
G
G
F
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
T712
N
K
D
M
V
L
K
T
K
K
N
G
G
F
Y
Chicken
Gallus gallus
NP_001025807
1020
114626
T671
N
N
D
M
V
L
K
T
K
K
N
G
G
F
Y
Frog
Xenopus laevis
NP_001085699
1022
114003
T674
N
R
D
M
V
L
K
T
K
R
D
G
G
F
F
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
K668
R
D
M
V
L
K
K
K
K
D
S
T
G
M
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
K671
A
P
L
A
L
K
P
K
K
N
Q
Q
G
W
Y
Honey Bee
Apis mellifera
XP_394050
958
109977
L635
K
C
G
L
D
M
T
L
K
D
R
K
Q
G
M
Nematode Worm
Caenorhab. elegans
O61660
759
85420
G442
T
E
K
F
H
A
S
G
L
R
I
R
D
M
G
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
W362
K
Q
T
Q
D
A
Q
W
G
A
F
A
G
N
L
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
Q590
E
V
L
A
T
C
L
Q
Q
M
K
A
C
F
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
K609
C
F
L
D
A
R
V
K
K
S
K
L
L
E
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
100
93.3
73.3
20
N.A.
20
6.6
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
93.3
100
40
N.A.
33.3
20
13.3
20
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
13
7
13
0
0
0
7
0
13
0
0
7
% A
% Cys:
7
7
0
0
0
7
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
7
57
7
13
0
0
0
0
13
7
0
7
0
0
% D
% Glu:
7
7
0
0
0
0
0
0
0
0
0
0
0
7
0
% E
% Phe:
0
7
0
7
0
0
0
0
0
0
7
0
0
63
7
% F
% Gly:
0
0
7
0
0
0
0
7
7
0
0
57
75
7
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% I
% Lys:
13
44
7
0
0
13
63
19
82
50
13
7
0
0
0
% K
% Leu:
0
0
19
7
13
57
7
7
7
0
0
7
7
0
19
% L
% Met:
0
0
7
57
0
7
0
0
0
7
0
0
0
13
7
% M
% Asn:
57
7
0
0
0
0
0
0
0
7
38
0
0
7
0
% N
% Pro:
0
7
0
0
0
0
7
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
7
0
0
7
7
7
0
7
7
7
0
0
% Q
% Arg:
7
7
0
0
0
7
0
0
0
13
7
7
0
0
0
% R
% Ser:
0
0
0
0
0
0
7
0
0
7
19
0
0
0
0
% S
% Thr:
7
0
7
0
7
0
7
57
0
0
0
7
0
0
0
% T
% Val:
0
7
0
7
57
0
7
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
57
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _