Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 26.06
Human Site: T728 Identified Species: 38.22
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 T728 K R G S L P P T M P L E F V C
Chimpanzee Pan troglodytes XP_511323 1001 112378 T728 K R G S L P P T M P L E F V C
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 T728 K R G S L P P T M P L E F V C
Dog Lupus familis XP_546656 989 110956 T728 K R G S L P P T M P L E F V G
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 A728 K R G S L P P A M P L E F V G
Rat Rattus norvegicus XP_002742497 1001 111922 S726 K R G S L P P S M P L E F V G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 T771 K R G S I P P T M P L E F V G
Chicken Gallus gallus NP_001025807 1020 114626 T730 K R G S V P P T M P L D F V G
Frog Xenopus laevis NP_001085699 1022 114003 L733 K R G S I P P L M P L E F V G
Zebra Danio Brachydanio rerio XP_688695 998 112490 M727 K R G S L P P M M P L E F V G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 F730 T P Y Y R G V F G T P S G W Y
Honey Bee Apis mellifera XP_394050 958 109977 Q694 R D S N I K S Q N P I T D D S
Nematode Worm Caenorhab. elegans O61660 759 85420 D501 A D L I S L M D K Y G I G T D
Sea Urchin Strong. purpuratus XP_782119 679 77025 A421 L A C C S Q D A Q G K E T I V
Poplar Tree Populus trichocarpa XP_002307047 910 102138 R649 N M V L K K N R D G N F M V G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 P668 M V G C M N Y P Q C R N A V W
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. 86.6 80 80 86.6 N.A. 0 6.6 0 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 86.6 93.3 N.A. 93.3 93.3 86.6 86.6 N.A. 0 33.3 0 13.3
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 6.6 N.A. N.A. 13.3 N.A. N.A.
P-Site Similarity: 6.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 0 0 0 13 0 0 0 0 7 0 0 % A
% Cys: 0 0 7 13 0 0 0 0 0 7 0 0 0 0 19 % C
% Asp: 0 13 0 0 0 0 7 7 7 0 0 7 7 7 7 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 63 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 7 0 0 0 7 63 0 0 % F
% Gly: 0 0 69 0 0 7 0 0 7 13 7 0 13 0 50 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 7 19 0 0 0 0 0 7 7 0 7 0 % I
% Lys: 63 0 0 0 7 13 0 0 7 0 7 0 0 0 0 % K
% Leu: 7 0 7 7 44 7 0 7 0 0 63 0 0 0 0 % L
% Met: 7 7 0 0 7 0 7 7 63 0 0 0 7 0 0 % M
% Asn: 7 0 0 7 0 7 7 0 7 0 7 7 0 0 0 % N
% Pro: 0 7 0 0 0 63 63 7 0 69 7 0 0 0 0 % P
% Gln: 0 0 0 0 0 7 0 7 13 0 0 0 0 0 0 % Q
% Arg: 7 63 0 0 7 0 0 7 0 0 7 0 0 0 0 % R
% Ser: 0 0 7 63 13 0 7 7 0 0 0 7 0 0 7 % S
% Thr: 7 0 0 0 0 0 0 38 0 7 0 7 7 7 0 % T
% Val: 0 7 7 0 7 0 7 0 0 0 0 0 0 75 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 7 % W
% Tyr: 0 0 7 7 0 0 7 0 0 7 0 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _