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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 11.82
Human Site: T823 Identified Species: 17.33
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 T823 G Q E A V L L T V R K E G P N
Chimpanzee Pan troglodytes XP_511323 1001 112378 T823 G Q E A V L L T V R K E G P N
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 T823 G Q E A V L L T V R K E G P N
Dog Lupus familis XP_546656 989 110956 F823 G P N Q G R Q F Y K C G G G G
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 L823 N C G R E A V L L T V R K Q G
Rat Rattus norvegicus XP_002742497 1001 111922 L821 N C G R E A V L L T V R K Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 L866 C N C G Q E A L L L T V R K D
Chicken Gallus gallus NP_001025807 1020 114626 C825 D G N N A V V C N C G N E A M
Frog Xenopus laevis NP_001085699 1022 114003 N828 E S N E V V C N C G V A A V Q
Zebra Danio Brachydanio rerio XP_688695 998 112490 L822 C N C G Q D A L L L T V R K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 S825 G G S G G W G S G T G G G G L
Honey Bee Apis mellifera XP_394050 958 109977 I789 N E N A I Q L I V R K E G P N
Nematode Worm Caenorhab. elegans O61660 759 85420 K596 I F V E S E R K I G V L S Q S
Sea Urchin Strong. purpuratus XP_782119 679 77025 T516 T H A E H I E T I K S R L Y V
Poplar Tree Populus trichocarpa XP_002307047 910 102138 T744 G G N G P P T T T P S N P Q R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 Q763 I Q G S N T R Q S N V C I H C
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 13.3 N.A. 0 0 N.A. 0 0 6.6 0 N.A. 13.3 60 0 6.6
P-Site Similarity: 100 100 100 20 N.A. 13.3 13.3 N.A. 13.3 13.3 13.3 6.6 N.A. 20 73.3 13.3 26.6
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 13.3 N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 25 7 13 13 0 0 0 0 7 7 7 0 % A
% Cys: 13 13 13 0 0 0 7 7 7 7 7 7 0 0 7 % C
% Asp: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % D
% Glu: 7 7 19 19 13 13 7 0 0 0 0 25 7 0 7 % E
% Phe: 0 7 0 0 0 0 0 7 0 0 0 0 0 0 0 % F
% Gly: 38 19 19 25 13 0 7 0 7 13 13 13 38 13 19 % G
% His: 0 7 0 0 7 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 13 0 0 0 7 7 0 7 13 0 0 0 7 0 0 % I
% Lys: 0 0 0 0 0 0 0 7 0 13 25 0 13 13 0 % K
% Leu: 0 0 0 0 0 19 25 25 25 13 0 7 7 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 19 13 32 7 7 0 0 7 7 7 0 13 0 0 25 % N
% Pro: 0 7 0 0 7 7 0 0 0 7 0 0 7 25 0 % P
% Gln: 0 25 0 7 13 7 7 7 0 0 0 0 0 25 7 % Q
% Arg: 0 0 0 13 0 7 13 0 0 25 0 19 13 0 7 % R
% Ser: 0 7 7 7 7 0 0 7 7 0 13 0 7 0 7 % S
% Thr: 7 0 0 0 0 7 7 32 7 19 13 0 0 0 0 % T
% Val: 0 0 7 0 25 13 19 0 25 0 32 13 0 7 7 % V
% Trp: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _