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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
30.91
Human Site:
T907
Identified Species:
45.33
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T907
S
Q
P
S
V
T
R
T
V
Q
K
D
G
P
N
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T907
S
Q
P
S
V
T
R
T
V
Q
K
D
G
P
N
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
T907
S
Q
P
A
V
T
R
T
V
Q
K
D
G
P
N
Dog
Lupus familis
XP_546656
989
110956
K898
A
V
T
R
T
V
Q
K
D
G
P
N
K
G
R
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
T909
G
Q
P
A
V
T
R
T
V
Q
K
D
G
P
N
Rat
Rattus norvegicus
XP_002742497
1001
111922
T907
G
Q
P
A
V
T
R
T
V
Q
K
D
G
P
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
V949
N
Q
P
A
I
T
R
V
V
Q
K
D
G
P
N
Chicken
Gallus gallus
NP_001025807
1020
114626
T926
D
Q
P
A
V
T
R
T
V
Q
K
D
G
P
N
Frog
Xenopus laevis
NP_001085699
1022
114003
T923
N
Q
P
A
V
T
R
T
V
Q
K
D
G
A
N
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
N903
D
E
G
E
T
M
C
N
C
N
E
P
S
V
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
T1046
Q
Q
P
A
R
Q
N
T
V
R
K
N
G
P
N
Honey Bee
Apis mellifera
XP_394050
958
109977
I866
N
Q
L
A
T
T
R
I
V
K
K
D
G
P
N
Nematode Worm
Caenorhab. elegans
O61660
759
85420
D670
P
A
V
K
N
G
H
D
D
P
E
N
D
T
I
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
I590
D
K
Y
K
Q
V
F
I
E
A
A
R
K
A
T
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
K819
T
A
N
N
R
G
R
K
F
Y
S
C
S
S
Q
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
S837
S
C
P
T
Q
G
C
S
F
F
A
W
E
D
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
93.3
0
N.A.
86.6
86.6
N.A.
73.3
86.6
80
0
N.A.
53.3
60
0
0
P-Site Similarity:
100
100
100
20
N.A.
93.3
93.3
N.A.
93.3
93.3
93.3
13.3
N.A.
73.3
80
13.3
6.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
13
0
50
0
0
0
0
0
7
13
0
0
13
0
% A
% Cys:
0
7
0
0
0
0
13
0
7
0
0
7
0
0
0
% C
% Asp:
19
0
0
0
0
0
0
7
13
0
0
57
7
7
0
% D
% Glu:
0
7
0
7
0
0
0
0
7
0
13
0
7
0
0
% E
% Phe:
0
0
0
0
0
0
7
0
13
7
0
0
0
0
0
% F
% Gly:
13
0
7
0
0
19
0
0
0
7
0
0
63
7
0
% G
% His:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
7
0
0
13
0
0
0
0
0
0
7
% I
% Lys:
0
7
0
13
0
0
0
13
0
7
63
0
13
0
0
% K
% Leu:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
0
7
7
7
0
7
7
0
7
0
19
0
0
63
% N
% Pro:
7
0
63
0
0
0
0
0
0
7
7
7
0
57
0
% P
% Gln:
7
63
0
0
13
7
7
0
0
50
0
0
0
0
7
% Q
% Arg:
0
0
0
7
13
0
63
0
0
7
0
7
0
0
7
% R
% Ser:
25
0
0
13
0
0
0
7
0
0
7
0
13
7
7
% S
% Thr:
7
0
7
7
19
57
0
50
0
0
0
0
0
7
13
% T
% Val:
0
7
7
0
44
13
0
7
63
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
7
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _