Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 36.06
Human Site: Y422 Identified Species: 52.89
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 Y422 P P I H P T K Y T N N L Q G D
Chimpanzee Pan troglodytes XP_511323 1001 112378 Y422 P P I H P T K Y T N S L Q G D
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 Y422 P P I H P T K Y T N S L Q G D
Dog Lupus familis XP_546656 989 110956 Y422 P P I H P T K Y T S S L Q G D
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 Y422 P P I H P T K Y T S G L Q G D
Rat Rattus norvegicus XP_002742497 1001 111922 S422 I H P T K Y T S S L Q G D D R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 Y465 P P I H P T K Y T C N L Q G D
Chicken Gallus gallus NP_001025807 1020 114626 Y424 P P I H P T K Y T A N L Q G N
Frog Xenopus laevis NP_001085699 1022 114003 Y427 P P I H P T K Y T N N L Q G N
Zebra Danio Brachydanio rerio XP_688695 998 112490 Y420 P P I H P T K Y T N G L Q G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 A416 P I H P T K L A E N L Q G N E
Honey Bee Apis mellifera XP_394050 958 109977 C390 P I H P I K Y C D N L N G N E
Nematode Worm Caenorhab. elegans O61660 759 85420 V235 Y K M I E N F V S E P F W K L
Sea Urchin Strong. purpuratus XP_782119 679 77025 T155 R A R F S E I T P Q S I T R A
Poplar Tree Populus trichocarpa XP_002307047 910 102138 P380 G A G L W R N P S N G G H D D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 P402 K A H P P I H P T K F S S G E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 93.3 93.3 86.6 N.A. 86.6 0 N.A. 93.3 86.6 93.3 86.6 N.A. 13.3 13.3 0 0
P-Site Similarity: 100 100 100 100 N.A. 93.3 6.6 N.A. 93.3 93.3 100 93.3 N.A. 20 20 13.3 13.3
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 20 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 0 0 0 7 0 7 0 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 7 0 7 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 7 0 0 0 7 13 44 % D
% Glu: 0 0 0 0 7 7 0 0 7 7 0 0 0 0 19 % E
% Phe: 0 0 0 7 0 0 7 0 0 0 7 7 0 0 0 % F
% Gly: 7 0 7 0 0 0 0 0 0 0 19 13 13 63 0 % G
% His: 0 7 19 57 0 0 7 0 0 0 0 0 7 0 0 % H
% Ile: 7 13 57 7 7 7 7 0 0 0 0 7 0 0 0 % I
% Lys: 7 7 0 0 7 13 57 0 0 7 0 0 0 7 0 % K
% Leu: 0 0 0 7 0 0 7 0 0 7 13 57 0 0 7 % L
% Met: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 7 7 0 0 50 25 7 0 13 19 % N
% Pro: 69 57 7 19 63 0 0 13 7 0 7 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 7 7 57 0 0 % Q
% Arg: 7 0 7 0 0 7 0 0 0 0 0 0 0 7 7 % R
% Ser: 0 0 0 0 7 0 0 7 19 13 25 7 7 0 0 % S
% Thr: 0 0 0 7 7 57 7 7 63 0 0 0 7 0 0 % T
% Val: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % W
% Tyr: 7 0 0 0 0 7 7 57 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _