Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP3A All Species: 44.24
Human Site: Y613 Identified Species: 64.89
UniProt: Q13472 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13472 NP_004609.1 1001 112372 Y613 L R Q Q V Q K Y K Q V F I E A
Chimpanzee Pan troglodytes XP_511323 1001 112378 Y613 L R Q Q V Q K Y K Q V F I E A
Rhesus Macaque Macaca mulatta XP_001095437 1001 112278 Y613 L R Q Q V Q K Y K Q V F I E A
Dog Lupus familis XP_546656 989 110956 Y613 L R Q Q V Q K Y K Q V F I E A
Cat Felis silvestris
Mouse Mus musculus O70157 1003 112340 Y613 L R Q Q V Q K Y K Q V F I E A
Rat Rattus norvegicus XP_002742497 1001 111922 Y611 L R Q Q V Q K Y K Q V F I E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510142 1042 116269 Y656 L T Q Q V Q K Y R Q V F I E A
Chicken Gallus gallus NP_001025807 1020 114626 Y615 L H Q Q V Q K Y K Q V F I E A
Frog Xenopus laevis NP_001085699 1022 114003 Y618 L R L Q I Q K Y K Q V F V E A
Zebra Danio Brachydanio rerio XP_688695 998 112490 Y611 L S Y H V A K Y K A V F I E S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9NG98 1250 136119 Y606 L T E Q I A K Y K Q A Y Q Q I
Honey Bee Apis mellifera XP_394050 958 109977 Y580 L E N Q I N K Y R D L F K I S
Nematode Worm Caenorhab. elegans O61660 759 85420 Q398 L K F T E K H Q L Q G D D W K
Sea Urchin Strong. purpuratus XP_782119 679 77025 Q318 R K L K I S A Q Q A M K I A E
Poplar Tree Populus trichocarpa XP_002307047 910 102138 G544 R F S P T N L G E A L V M G Y
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201197 926 103389 L565 Y D D M G Y E L W K P N L R A
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 94.9 87.7 N.A. 86.8 83.8 N.A. 72.8 73 70.9 66.5 N.A. 41.2 46.8 38.5 47
Protein Similarity: 100 99.6 97 91.1 N.A. 91.5 88.9 N.A. 80.5 82.9 81.8 80.3 N.A. 53.7 63.7 50.8 57
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 86.6 93.3 80 60 N.A. 40 33.3 13.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 93.3 93.3 93.3 66.6 N.A. 66.6 60 26.6 40
Percent
Protein Identity: 40 N.A. N.A. 38.8 N.A. N.A.
Protein Similarity: 56.3 N.A. N.A. 54.5 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 20 N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 13 7 0 0 19 7 0 0 7 63 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 7 0 0 0 0 0 0 7 0 7 7 0 0 % D
% Glu: 0 7 7 0 7 0 7 0 7 0 0 0 0 63 7 % E
% Phe: 0 7 7 0 0 0 0 0 0 0 0 69 0 0 0 % F
% Gly: 0 0 0 0 7 0 0 7 0 0 7 0 0 7 0 % G
% His: 0 7 0 7 0 0 7 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 25 0 0 0 0 0 0 0 63 7 7 % I
% Lys: 0 13 0 7 0 7 75 0 63 7 0 7 7 0 7 % K
% Leu: 82 0 13 0 0 0 7 7 7 0 13 0 7 0 0 % L
% Met: 0 0 0 7 0 0 0 0 0 0 7 0 7 0 0 % M
% Asn: 0 0 7 0 0 13 0 0 0 0 0 7 0 0 0 % N
% Pro: 0 0 0 7 0 0 0 0 0 0 7 0 0 0 0 % P
% Gln: 0 0 50 69 0 57 0 13 7 69 0 0 7 7 0 % Q
% Arg: 13 44 0 0 0 0 0 0 13 0 0 0 0 7 0 % R
% Ser: 0 7 7 0 0 7 0 0 0 0 0 0 0 0 13 % S
% Thr: 0 13 0 7 7 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 57 0 0 0 0 0 63 7 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 0 0 7 0 % W
% Tyr: 7 0 7 0 0 7 0 75 0 0 0 7 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _