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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMAD4
All Species:
20
Human Site:
T174
Identified Species:
36.67
UniProt:
Q13485
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13485
NP_005350.1
552
60439
T174
E
G
Q
P
S
L
S
T
E
G
H
S
I
Q
T
Chimpanzee
Pan troglodytes
XP_001155006
493
53820
H164
M
V
K
D
E
Y
V
H
D
F
E
G
Q
P
S
Rhesus Macaque
Macaca mulatta
XP_001095978
493
53880
H164
M
V
K
D
E
Y
V
H
D
F
E
G
Q
P
S
Dog
Lupus familis
XP_849370
552
60457
T174
E
G
Q
P
S
L
S
T
E
G
H
S
I
Q
T
Cat
Felis silvestris
Mouse
Mus musculus
P97471
551
60399
T173
E
G
Q
P
S
L
P
T
E
G
H
S
I
Q
T
Rat
Rattus norvegicus
O70437
552
60451
T174
E
G
Q
P
S
L
P
T
E
G
H
S
I
Q
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509486
552
60450
T174
E
G
Q
P
S
L
S
T
E
G
H
S
I
Q
T
Chicken
Gallus gallus
P84023
426
48233
L97
R
L
W
R
W
P
D
L
H
S
H
H
E
L
R
Frog
Xenopus laevis
NP_001090536
549
59837
S171
A
E
G
Q
Q
S
I
S
A
G
D
G
L
S
I
Zebra Danio
Brachydanio rerio
Q9I8V2
472
53048
N143
P
P
V
L
V
P
R
N
S
E
F
N
A
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P42003
455
50486
P126
P
L
E
L
C
Q
Y
P
F
S
A
K
Q
K
E
Honey Bee
Apis mellifera
XP_392838
578
62051
T198
V
G
G
G
S
S
A
T
A
G
A
V
G
S
A
Nematode Worm
Caenorhab. elegans
P45897
570
63351
L179
I
E
S
L
V
K
K
L
K
D
K
R
I
E
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.6
88
98.9
N.A.
98
98.7
N.A.
97.4
37.8
90.9
35.5
N.A.
36.9
66
26.4
N.A.
Protein Similarity:
100
88.7
88.9
99.2
N.A.
98.7
98.9
N.A.
98.5
51.4
94.3
50
N.A.
51
74
41.4
N.A.
P-Site Identity:
100
0
0
100
N.A.
93.3
93.3
N.A.
100
6.6
6.6
0
N.A.
0
26.6
6.6
N.A.
P-Site Similarity:
100
20
20
100
N.A.
93.3
93.3
N.A.
100
6.6
20
13.3
N.A.
13.3
33.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
16
0
16
0
8
0
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
16
0
0
8
0
16
8
8
0
0
0
0
% D
% Glu:
39
16
8
0
16
0
0
0
39
8
16
0
8
8
8
% E
% Phe:
0
0
0
0
0
0
0
0
8
16
8
0
0
0
0
% F
% Gly:
0
47
16
8
0
0
0
0
0
54
0
24
8
0
0
% G
% His:
0
0
0
0
0
0
0
16
8
0
47
8
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
0
0
0
0
47
0
8
% I
% Lys:
0
0
16
0
0
8
8
0
8
0
8
8
0
16
0
% K
% Leu:
0
16
0
24
0
39
0
16
0
0
0
0
8
8
16
% L
% Met:
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% N
% Pro:
16
8
0
39
0
16
16
8
0
0
0
0
0
16
0
% P
% Gln:
0
0
39
8
8
8
0
0
0
0
0
0
24
39
0
% Q
% Arg:
8
0
0
8
0
0
8
0
0
0
0
8
0
0
8
% R
% Ser:
0
0
8
0
47
16
24
8
8
16
0
39
0
16
16
% S
% Thr:
0
0
0
0
0
0
0
47
0
0
0
0
0
0
39
% T
% Val:
8
16
8
0
16
0
16
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
16
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _