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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PICALM All Species: 17.27
Human Site: T441 Identified Species: 31.67
UniProt: Q13492 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13492 NP_001008660.1 652 70755 T441 P S L N P F L T K S S G D V H
Chimpanzee Pan troglodytes XP_508908 793 85002 T582 P S L N P F L T K S S G D V H
Rhesus Macaque Macaca mulatta XP_001085480 907 92424 Q658 S E P Q P A S Q A A S S S S A
Dog Lupus familis XP_858235 652 70722 T441 P S L N P F L T K S S G D V H
Cat Felis silvestris
Mouse Mus musculus Q7M6Y3 660 71525 T441 P S L N P F L T K S S G D V H
Rat Rattus norvegicus O55012 640 69267 L429 V D D A I P S L N P F L T K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512668 642 69699 P423 P S L N P F L P K P P D A V H
Chicken Gallus gallus XP_423671 651 70667 T440 P N L N P F L T K T N D A A H
Frog Xenopus laevis NP_001085333 444 49230 L234 L E Q H L A S L E G K K T K E
Zebra Danio Brachydanio rerio NP_957221 589 63960 A379 P A I D L F S A T S T F A N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VI75 468 49849 M258 Y K K F L V R M D R V G E F L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XZI6 586 64045 A376 D V A S A A P A P A T S A A Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P53309 568 64310 P358 N D T F S F E P T Q P Q M T A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 81.2 45 99.3 N.A. 96.5 96.1 N.A. 89.7 94.1 47 77.1 N.A. 41.4 N.A. 38.7 N.A.
Protein Similarity: 100 81.3 56 99.6 N.A. 97.7 96.9 N.A. 92.1 97.3 57.6 83.4 N.A. 54.2 N.A. 55.6 N.A.
P-Site Identity: 100 100 13.3 100 N.A. 100 0 N.A. 66.6 60 0 20 N.A. 6.6 N.A. 0 N.A.
P-Site Similarity: 100 100 20 100 N.A. 100 0 N.A. 66.6 80 13.3 46.6 N.A. 13.3 N.A. 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.5 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 40.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 8 8 24 0 16 8 16 0 0 31 16 16 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 16 8 8 0 0 0 0 8 0 0 16 31 0 0 % D
% Glu: 0 16 0 0 0 0 8 0 8 0 0 0 8 0 8 % E
% Phe: 0 0 0 16 0 62 0 0 0 0 8 8 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 8 0 39 0 0 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 47 % H
% Ile: 0 0 8 0 8 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 8 8 0 0 0 0 0 47 0 8 8 0 16 0 % K
% Leu: 8 0 47 0 24 0 47 16 0 0 0 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % M
% Asn: 8 8 0 47 0 0 0 0 8 0 8 0 0 8 0 % N
% Pro: 54 0 8 0 54 8 8 16 8 16 16 0 0 0 0 % P
% Gln: 0 0 8 8 0 0 0 8 0 8 0 8 0 0 8 % Q
% Arg: 0 0 0 0 0 0 8 0 0 8 0 0 0 0 0 % R
% Ser: 8 39 0 8 8 0 31 0 0 39 39 16 8 8 16 % S
% Thr: 0 0 8 0 0 0 0 39 16 8 16 0 16 8 0 % T
% Val: 8 8 0 0 0 8 0 0 0 0 8 0 0 39 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _