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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRPF4B All Species: 27.88
Human Site: S356 Identified Species: 51.11
UniProt: Q13523 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13523 NP_003904.3 1007 116973 S356 S P K R R S L S P K P R D K S
Chimpanzee Pan troglodytes XP_518214 1087 126250 S436 S P K R R S L S P K P R D K S
Rhesus Macaque Macaca mulatta XP_001094163 1007 116833 S356 S P K R R S L S P K P R D K S
Dog Lupus familis XP_848551 1042 120804 S390 S P K R R S L S P K Q R D K S
Cat Felis silvestris
Mouse Mus musculus Q61136 1007 116929 S356 S P K R R S L S P K L R D K S
Rat Rattus norvegicus Q5RKH1 1007 116988 S356 S P K R R S L S P K Q R D K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508424 1011 117270 S359 S P K G R S S S P K Q R D K L
Chicken Gallus gallus XP_001232309 1005 116507 P355 P K G R S L S P K P R E K S R
Frog Xenopus laevis NP_001088314 991 115012 L341 W S P K A R S L S P K Q R D R
Zebra Danio Brachydanio rerio NP_998614 1010 116034 S372 P Q H R R S S S P R H R D R Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_612010 907 104024 D339 R D H S R D R D R R G L D R P
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_492008 775 90931 K249 R R I Q I I K K I E G H T E E
Sea Urchin Strong. purpuratus XP_791787 924 105587 R326 L K S G E K S R R E S S R D S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.6 99 95.3 N.A. 95.1 95.4 N.A. 93 89.7 80.6 68.8 N.A. 41.4 N.A. 36.8 48.3
Protein Similarity: 100 92.6 99.3 96.1 N.A. 97.5 97.8 N.A. 96.5 94 89.4 78.4 N.A. 57.4 N.A. 51.9 59.9
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 73.3 6.6 0 46.6 N.A. 13.3 N.A. 0 6.6
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 73.3 6.6 13.3 60 N.A. 26.6 N.A. 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 0 8 0 8 0 0 0 0 70 16 0 % D
% Glu: 0 0 0 0 8 0 0 0 0 16 0 8 0 8 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 16 0 0 0 0 0 0 16 0 0 0 0 % G
% His: 0 0 16 0 0 0 0 0 0 0 8 8 0 0 0 % H
% Ile: 0 0 8 0 8 8 0 0 8 0 0 0 0 0 0 % I
% Lys: 0 16 54 8 0 8 8 8 8 54 8 0 8 54 0 % K
% Leu: 8 0 0 0 0 8 47 8 0 0 8 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 16 54 8 0 0 0 0 8 62 16 24 0 0 0 8 % P
% Gln: 0 8 0 8 0 0 0 0 0 0 24 8 0 0 8 % Q
% Arg: 16 8 0 62 70 8 8 8 16 16 8 62 16 16 16 % R
% Ser: 54 8 8 8 8 62 39 62 8 0 8 8 0 8 54 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _