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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4B
All Species:
10.3
Human Site:
T259
Identified Species:
18.89
UniProt:
Q13523
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13523
NP_003904.3
1007
116973
T259
I
G
K
A
R
S
P
T
D
D
K
V
K
I
E
Chimpanzee
Pan troglodytes
XP_518214
1087
126250
T339
I
G
K
A
R
S
P
T
D
D
K
V
K
I
E
Rhesus Macaque
Macaca mulatta
XP_001094163
1007
116833
T259
I
G
K
A
R
S
P
T
D
D
K
V
K
I
E
Dog
Lupus familis
XP_848551
1042
120804
P293
I
G
K
A
R
S
P
P
D
D
K
V
K
I
E
Cat
Felis silvestris
Mouse
Mus musculus
Q61136
1007
116929
P259
K
V
G
K
A
R
S
P
A
E
E
K
M
K
S
Rat
Rattus norvegicus
Q5RKH1
1007
116988
P259
K
V
G
K
A
R
S
P
A
D
E
K
I
K
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508424
1011
117270
M262
I
G
K
A
K
S
P
M
E
E
K
L
K
T
E
Chicken
Gallus gallus
XP_001232309
1005
116507
P258
N
R
K
S
K
S
P
P
D
D
R
N
K
A
D
Frog
Xenopus laevis
NP_001088314
991
115012
K244
L
R
H
Q
S
P
E
K
N
I
K
T
K
S
P
Zebra Danio
Brachydanio rerio
NP_998614
1010
116034
P275
R
G
K
K
S
Q
S
P
S
I
R
R
H
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_612010
907
104024
S242
K
K
S
T
T
H
N
S
N
E
S
D
V
I
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_492008
775
90931
Q152
S
K
E
R
R
L
I
Q
R
K
R
E
D
N
R
Sea Urchin
Strong. purpuratus
XP_791787
924
105587
H229
E
T
S
Q
K
K
Q
H
R
S
K
S
P
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.6
99
95.3
N.A.
95.1
95.4
N.A.
93
89.7
80.6
68.8
N.A.
41.4
N.A.
36.8
48.3
Protein Similarity:
100
92.6
99.3
96.1
N.A.
97.5
97.8
N.A.
96.5
94
89.4
78.4
N.A.
57.4
N.A.
51.9
59.9
P-Site Identity:
100
100
100
93.3
N.A.
0
6.6
N.A.
60
40
13.3
13.3
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
13.3
13.3
N.A.
86.6
66.6
26.6
20
N.A.
26.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
39
16
0
0
0
16
0
0
0
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
39
47
0
8
8
0
8
% D
% Glu:
8
0
8
0
0
0
8
0
8
24
16
8
0
0
39
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
47
16
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
8
0
0
8
0
8
0
0
0
0
8
0
0
% H
% Ile:
39
0
0
0
0
0
8
0
0
16
0
0
8
39
0
% I
% Lys:
24
16
54
24
24
8
0
8
0
8
54
16
54
16
0
% K
% Leu:
8
0
0
0
0
8
0
0
0
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% M
% Asn:
8
0
0
0
0
0
8
0
16
0
0
8
0
8
0
% N
% Pro:
0
0
0
0
0
8
47
39
0
0
0
0
8
0
8
% P
% Gln:
0
0
0
16
0
8
8
8
0
0
0
0
0
0
0
% Q
% Arg:
8
16
0
8
39
16
0
0
16
0
24
8
0
0
8
% R
% Ser:
8
0
16
8
16
47
24
8
8
8
8
8
0
16
16
% S
% Thr:
0
8
0
8
8
0
0
24
0
0
0
8
0
8
8
% T
% Val:
0
16
0
0
0
0
0
0
0
0
0
31
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _