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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
22.73
Human Site:
S434
Identified Species:
33.33
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Chimpanzee
Pan troglodytes
XP_519834
482
55098
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
S443
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Dog
Lupus familis
XP_544435
482
55144
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Rat
Rattus norvegicus
Q4QQW4
482
55074
S434
G
E
G
G
R
K
N
S
S
N
F
K
K
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
E415
D
K
R
I
A
C
D
E
E
F
S
D
S
E
D
Chicken
Gallus gallus
P56517
480
54920
V434
G
E
G
G
R
K
N
V
A
N
F
K
K
A
K
Frog
Xenopus laevis
O42227
480
54874
V434
G
E
G
G
R
K
N
V
A
N
F
K
K
V
K
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
R389
S
D
L
L
S
Y
E
R
P
D
E
A
D
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
N432
G
E
G
G
R
R
D
N
R
S
Y
K
G
Q
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
Q422
Q
I
T
D
G
M
I
Q
D
D
G
D
F
Y
D
Sea Urchin
Strong. purpuratus
P56518
576
64060
E434
G
E
T
R
L
P
G
E
G
G
R
R
D
H
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
R442
I
L
G
I
K
I
K
R
E
F
G
E
N
A
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
I427
V
D
D
D
R
K
P
I
P
S
R
V
K
R
E
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
P395
S
V
Q
L
N
H
T
P
R
D
A
E
D
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
86.6
80
0
N.A.
40
N.A.
0
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
93.3
86.6
20
N.A.
80
N.A.
6.6
26.6
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
13.3
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
13
0
7
7
0
50
0
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
13
7
13
0
0
13
0
7
19
0
13
19
0
13
% D
% Glu:
0
63
0
0
0
0
7
13
13
0
7
13
0
7
13
% E
% Phe:
0
0
0
0
0
0
0
0
0
13
50
0
7
0
0
% F
% Gly:
63
0
63
57
7
0
7
0
7
7
13
0
7
0
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
7
0
% H
% Ile:
7
7
0
13
0
7
7
7
0
0
0
0
0
0
0
% I
% Lys:
0
7
0
0
7
57
7
0
0
0
0
57
57
0
50
% K
% Leu:
0
7
7
13
7
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
50
7
0
50
0
0
7
0
0
% N
% Pro:
0
0
0
0
0
7
7
7
13
0
0
0
0
7
0
% P
% Gln:
7
0
7
0
0
0
0
7
0
0
0
0
0
7
0
% Q
% Arg:
0
0
7
7
63
7
0
13
13
0
13
7
0
7
13
% R
% Ser:
13
0
0
0
7
0
0
38
38
13
7
0
7
0
0
% S
% Thr:
0
0
13
0
0
0
7
0
0
0
0
0
0
0
7
% T
% Val:
7
7
0
0
0
0
0
13
0
0
0
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
7
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _