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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC1
All Species:
43.64
Human Site:
Y72
Identified Species:
64
UniProt:
Q13547
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13547
NP_004955.2
482
55103
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Chimpanzee
Pan troglodytes
XP_519834
482
55098
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Rhesus Macaque
Macaca mulatta
XP_001096929
485
54378
Y81
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Dog
Lupus familis
XP_544435
482
55144
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Cat
Felis silvestris
Mouse
Mus musculus
O09106
482
55056
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Rat
Rattus norvegicus
Q4QQW4
482
55074
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521848
455
51607
R74
D
E
Y
I
K
F
L
R
S
I
R
P
D
N
M
Chicken
Gallus gallus
P56517
480
54920
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Frog
Xenopus laevis
O42227
480
54874
Y72
T
K
Y
H
S
D
D
Y
I
K
F
L
R
S
I
Zebra Danio
Brachydanio rerio
Q803C3
428
48962
D57
P
Y
K
A
S
Q
H
D
M
C
R
F
H
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q94517
521
58312
R75
D
E
Y
V
R
F
L
R
S
I
R
P
D
N
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O17695
461
52119
Y76
T
R
F
H
S
D
E
Y
M
T
F
L
K
S
A
Sea Urchin
Strong. purpuratus
P56518
576
64060
V72
K
Y
H
S
D
D
Y
V
K
F
L
R
T
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P56521
513
57528
Y86
C
R
F
H
A
E
E
Y
I
N
F
L
R
S
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22446
501
56004
Y80
C
R
F
H
A
D
D
Y
V
S
F
L
R
S
I
Baker's Yeast
Sacchar. cerevisiae
P32561
433
48886
R65
Y
K
K
M
E
I
Y
R
A
K
P
A
T
K
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
88.4
99.1
N.A.
99.3
99.1
N.A.
83.4
93.3
91
54.3
N.A.
71.9
N.A.
59.5
69.6
Protein Similarity:
100
100
90.7
99.5
N.A.
100
100
N.A.
89
96.4
96.8
71.3
N.A.
82.1
N.A.
77.5
77.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
100
13.3
N.A.
6.6
N.A.
53.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
100
100
20
N.A.
26.6
N.A.
86.6
13.3
Percent
Protein Identity:
N.A.
53.2
N.A.
56.6
54.5
N.A.
Protein Similarity:
N.A.
69.9
N.A.
71
70.1
N.A.
P-Site Identity:
N.A.
46.6
N.A.
60
13.3
N.A.
P-Site Similarity:
N.A.
86.6
N.A.
86.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
13
0
0
0
7
0
0
7
0
0
7
% A
% Cys:
13
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% C
% Asp:
13
0
0
0
7
69
57
7
0
0
0
0
13
0
0
% D
% Glu:
0
13
0
0
7
7
13
0
0
0
0
0
0
0
7
% E
% Phe:
0
0
19
0
0
13
0
0
0
7
69
7
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
7
69
0
0
7
0
0
0
0
0
7
0
0
% H
% Ile:
0
0
0
7
0
7
0
0
57
13
0
0
0
7
57
% I
% Lys:
7
57
13
0
7
0
0
0
7
57
0
0
7
7
0
% K
% Leu:
0
0
0
0
0
0
13
0
0
0
7
69
0
0
0
% L
% Met:
0
0
0
7
0
0
0
0
13
0
0
0
0
0
13
% M
% Asn:
0
0
0
0
0
0
0
0
0
7
0
0
0
13
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
7
13
0
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% Q
% Arg:
0
19
0
0
7
0
0
19
0
0
19
7
63
0
7
% R
% Ser:
0
0
0
7
63
0
0
0
13
7
0
0
0
75
0
% S
% Thr:
57
0
0
0
0
0
0
0
0
7
0
0
13
0
0
% T
% Val:
0
0
0
7
0
0
0
7
7
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
13
63
0
0
0
13
69
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _