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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PWP1 All Species: 16.36
Human Site: S249 Identified Species: 32.73
UniProt: Q13610 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13610 NP_008993.1 501 55828 S249 K K K K G K K S S S A E G H T
Chimpanzee Pan troglodytes XP_001162437 430 48207 V178 Q E E D S F Y V H H D I L L S
Rhesus Macaque Macaca mulatta XP_001093636 372 41113 Y121 S L L G L T V Y G S N D Q D P
Dog Lupus familis XP_531756 500 55840 S248 K K K K G K K S S S A E G H T
Cat Felis silvestris
Mouse Mus musculus Q99LL5 501 55568 S248 K K K K G K K S S S A E G H T
Rat Rattus norvegicus XP_343187 500 55792 S248 K K K K G K K S S S A E G H T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508747 534 59511 V278 K K K K G K K V S T P E G H T
Chicken Gallus gallus
Frog Xenopus laevis NP_001084632 504 56148 E253 G K K G A S S E E T Q E G H S
Zebra Danio Brachydanio rerio NP_956586 490 54644 K237 S L G S K K E K K K K K K A K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_396674 460 52260 K209 P I Y K L G C K A N K K K N R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_788925 939 103869 T649 K K S K Q K P T A P S L N G H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P21304 576 63785 N295 A V L S M A H N K Y F R S V L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.8 73.2 98.8 N.A. 89.8 90.2 N.A. 75.6 N.A. 69.8 70 N.A. N.A. 38.9 N.A. 29.7
Protein Similarity: 100 85.8 73.6 99.1 N.A. 94 94.8 N.A. 84 N.A. 83.9 84.2 N.A. N.A. 58.6 N.A. 40.1
P-Site Identity: 100 0 6.6 100 N.A. 100 100 N.A. 80 N.A. 33.3 6.6 N.A. N.A. 6.6 N.A. 26.6
P-Site Similarity: 100 26.6 13.3 100 N.A. 100 100 N.A. 86.6 N.A. 46.6 20 N.A. N.A. 33.3 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 30.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 9 9 0 0 17 0 34 0 0 9 0 % A
% Cys: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 9 0 0 0 0 0 0 9 9 0 9 0 % D
% Glu: 0 9 9 0 0 0 9 9 9 0 0 50 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 9 0 0 0 0 % F
% Gly: 9 0 9 17 42 9 0 0 9 0 0 0 50 9 0 % G
% His: 0 0 0 0 0 0 9 0 9 9 0 0 0 50 9 % H
% Ile: 0 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % I
% Lys: 50 59 50 59 9 59 42 17 17 9 17 17 17 0 9 % K
% Leu: 0 17 17 0 17 0 0 0 0 0 0 9 9 9 9 % L
% Met: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 9 9 0 9 9 0 % N
% Pro: 9 0 0 0 0 0 9 0 0 9 9 0 0 0 9 % P
% Gln: 9 0 0 0 9 0 0 0 0 0 9 0 9 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 9 % R
% Ser: 17 0 9 17 9 9 9 34 42 42 9 0 9 0 17 % S
% Thr: 0 0 0 0 0 9 0 9 0 17 0 0 0 0 42 % T
% Val: 0 9 0 0 0 0 9 17 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 9 0 0 0 9 9 0 9 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _