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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL1 All Species: 48.18
Human Site: S481 Identified Species: 75.71
UniProt: Q13616 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13616 NP_003583.2 776 89679 S481 L V H Q N S A S D D A E A S M
Chimpanzee Pan troglodytes XP_001165296 760 88111 S465 L V H Q N S A S D D A E A S M
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848402 776 89643 S481 L V H Q N S A S D D A E A S M
Cat Felis silvestris
Mouse Mus musculus Q9WTX6 776 89673 S481 L V H Q N S A S D D A E A S M
Rat Rattus norvegicus Q9JJ31 780 90872 E473 I S A D S E I E E N M V E W L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505554 776 89705 S481 L V H Q N S A S D D A E A S M
Chicken Gallus gallus XP_418878 774 89674 S479 L V H Q N S A S D D A E A S M
Frog Xenopus laevis Q6DE95 768 88933 S447 L L T N K S V S D D S E K N M
Zebra Danio Brachydanio rerio NP_955953 777 90010 S482 L V H Q N S A S D D A E A S M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 S480 L V N H T S A S D D A E A M M
Honey Bee Apis mellifera XP_394044 777 89569 S485 L V Q H M S A S D D A E A S M
Nematode Worm Caenorhab. elegans Q17389 780 89509 S485 L I S E L S A S D E A E A N F
Sea Urchin Strong. purpuratus XP_794360 770 89058 S480 L V H H N S A S D D A E A S M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 N448 L L F D R S A N D D H E R S I
Baker's Yeast Sacchar. cerevisiae Q12018 815 93926 S496 L I H G T S T S A E D E E N I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 99.7 N.A. 99.8 31.5 N.A. 99.7 97 31.8 96.5 N.A. 63.6 78.2 46.9 81.7
Protein Similarity: 100 97.9 N.A. 99.7 N.A. 99.8 53.4 N.A. 99.8 98 54.5 97.6 N.A. 77.9 87.9 65.5 91.2
P-Site Identity: 100 100 N.A. 100 N.A. 100 0 N.A. 100 100 46.6 100 N.A. 73.3 80 53.3 93.3
P-Site Similarity: 100 100 N.A. 100 N.A. 100 33.3 N.A. 100 100 66.6 100 N.A. 80 80 80 93.3
Percent
Protein Identity: N.A. N.A. N.A. 31.9 33.6 N.A.
Protein Similarity: N.A. N.A. N.A. 52.5 55 N.A.
P-Site Identity: N.A. N.A. N.A. 46.6 33.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 66.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 80 0 7 0 74 0 74 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 14 0 0 0 0 87 80 7 0 0 0 0 % D
% Glu: 0 0 0 7 0 7 0 7 7 14 0 94 14 0 0 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 7 % F
% Gly: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 60 20 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 14 0 0 0 0 7 0 0 0 0 0 0 0 14 % I
% Lys: 0 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % K
% Leu: 94 14 0 0 7 0 0 0 0 0 0 0 0 0 7 % L
% Met: 0 0 0 0 7 0 0 0 0 0 7 0 0 7 74 % M
% Asn: 0 0 7 7 54 0 0 7 0 7 0 0 0 20 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 47 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 7 0 0 0 0 0 0 0 7 0 0 % R
% Ser: 0 7 7 0 7 94 0 87 0 0 7 0 0 67 0 % S
% Thr: 0 0 7 0 14 0 7 0 0 0 0 0 0 0 0 % T
% Val: 0 67 0 0 0 0 7 0 0 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _