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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL1 All Species: 19.7
Human Site: S70 Identified Species: 30.95
UniProt: Q13616 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13616 NP_003583.2 776 89679 S70 R G A G V P P S K S K K G Q T
Chimpanzee Pan troglodytes XP_001165296 760 88111 L70 R G A G F V G L E L Y K R L K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848402 776 89643 S70 R G A G V P P S K S K K G Q T
Cat Felis silvestris
Mouse Mus musculus Q9WTX6 776 89673 S70 R G A G V P P S K S K K G Q T
Rat Rattus norvegicus Q9JJ31 780 90872 D68 I H Q A L K E D I L E F I K Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505554 776 89705 S70 R G A G V P P S K S K K G Q T
Chicken Gallus gallus XP_418878 774 89674 S70 R G A G V P P S K S K K G Q T
Frog Xenopus laevis Q6DE95 768 88933 R59 L S F E E L Y R N A Y T M V L
Zebra Danio Brachydanio rerio NP_955953 777 90010 K71 G G G P A P S K P S K K T P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 S61 T S V S A A P S G R S S G K T
Honey Bee Apis mellifera XP_394044 777 89569 K74 Q L T R T S T K S K K G Q I S
Nematode Worm Caenorhab. elegans Q17389 780 89509 A66 R D G E D G R A E S S T P A R
Sea Urchin Strong. purpuratus XP_794360 770 89058 A69 Q Q A R T T S A K S K K G T V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 Q61 P P H D Y S Q Q L Y D K Y R E
Baker's Yeast Sacchar. cerevisiae Q12018 815 93926 R64 N Y C V N K S R S S G H F S T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 N.A. 99.7 N.A. 99.8 31.5 N.A. 99.7 97 31.8 96.5 N.A. 63.6 78.2 46.9 81.7
Protein Similarity: 100 97.9 N.A. 99.7 N.A. 99.8 53.4 N.A. 99.8 98 54.5 97.6 N.A. 77.9 87.9 65.5 91.2
P-Site Identity: 100 33.3 N.A. 100 N.A. 100 0 N.A. 100 100 0 40 N.A. 26.6 6.6 13.3 40
P-Site Similarity: 100 40 N.A. 100 N.A. 100 20 N.A. 100 100 6.6 40 N.A. 33.3 20 26.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. 31.9 33.6 N.A.
Protein Similarity: N.A. N.A. N.A. 52.5 55 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 47 7 14 7 0 14 0 7 0 0 0 7 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 7 0 7 7 0 0 7 0 0 7 0 0 0 0 % D
% Glu: 0 0 0 14 7 0 7 0 14 0 7 0 0 0 7 % E
% Phe: 0 0 7 0 7 0 0 0 0 0 0 7 7 0 0 % F
% Gly: 7 47 14 40 0 7 7 0 7 0 7 7 47 0 0 % G
% His: 0 7 7 0 0 0 0 0 0 0 0 7 0 0 0 % H
% Ile: 7 0 0 0 0 0 0 0 7 0 0 0 7 7 0 % I
% Lys: 0 0 0 0 0 14 0 14 40 7 54 60 0 14 7 % K
% Leu: 7 7 0 0 7 7 0 7 7 14 0 0 0 7 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 7 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % N
% Pro: 7 7 0 7 0 40 40 0 7 0 0 0 7 7 0 % P
% Gln: 14 7 7 0 0 0 7 7 0 0 0 0 7 34 7 % Q
% Arg: 47 0 0 14 0 0 7 14 0 7 0 0 7 7 7 % R
% Ser: 0 14 0 7 0 14 20 40 14 60 14 7 0 7 7 % S
% Thr: 7 0 7 0 14 7 7 0 0 0 0 14 7 7 54 % T
% Val: 0 0 7 7 34 7 0 0 0 0 0 0 0 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 7 0 7 0 0 7 14 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _