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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL1
All Species:
38.18
Human Site:
Y244
Identified Species:
60
UniProt:
Q13616
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13616
NP_003583.2
776
89679
Y244
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Chimpanzee
Pan troglodytes
XP_001165296
760
88111
P240
T
E
F
L
Q
Q
N
P
V
T
E
Y
M
K
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848402
776
89643
Y244
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTX6
776
89673
Y244
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Rat
Rattus norvegicus
Q9JJ31
780
90872
L246
K
E
E
E
K
R
A
L
R
Y
L
E
T
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505554
776
89705
Y244
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Chicken
Gallus gallus
XP_418878
774
89674
Y242
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Frog
Xenopus laevis
Q6DE95
768
88933
S229
Q
K
F
L
A
E
N
S
A
S
V
Y
I
K
K
Zebra Danio
Brachydanio rerio
NP_955953
777
90010
Y245
L
A
D
T
E
R
F
Y
T
R
E
S
T
E
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
Y235
I
A
D
T
S
A
F
Y
E
K
E
S
D
A
F
Honey Bee
Apis mellifera
XP_394044
777
89569
Y248
L
E
D
T
E
R
F
Y
T
R
E
S
S
E
F
Nematode Worm
Caenorhab. elegans
Q17389
780
89509
Y244
L
E
A
T
R
G
F
Y
T
Q
E
A
A
N
F
Sea Urchin
Strong. purpuratus
XP_794360
770
89058
Y243
L
S
E
T
E
R
F
Y
T
S
E
S
T
E
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
R234
C
L
K
K
E
R
E
R
V
A
H
Y
L
H
S
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
T237
K
K
T
Q
E
Y
Y
T
Q
Y
T
N
D
Y
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
99.7
N.A.
99.8
31.5
N.A.
99.7
97
31.8
96.5
N.A.
63.6
78.2
46.9
81.7
Protein Similarity:
100
97.9
N.A.
99.7
N.A.
99.8
53.4
N.A.
99.8
98
54.5
97.6
N.A.
77.9
87.9
65.5
91.2
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
13.3
N.A.
100
100
0
100
N.A.
53.3
86.6
46.6
80
P-Site Similarity:
100
26.6
N.A.
100
N.A.
100
26.6
N.A.
100
100
6.6
100
N.A.
66.6
93.3
60
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
33.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
55
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
47
7
0
7
7
7
0
7
7
0
7
7
7
0
% A
% Cys:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
54
0
0
0
0
0
0
0
0
0
14
0
0
% D
% Glu:
0
27
14
7
67
7
7
0
7
0
74
7
0
54
0
% E
% Phe:
0
0
14
0
0
0
67
0
0
0
0
0
0
0
67
% F
% Gly:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
7
0
% H
% Ile:
7
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% I
% Lys:
14
14
7
7
7
0
0
0
0
7
0
0
0
14
14
% K
% Leu:
60
7
0
14
0
0
0
7
0
0
7
0
7
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
14
0
0
0
0
7
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% P
% Gln:
7
0
0
7
7
7
0
0
7
7
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
67
0
7
7
47
0
0
0
7
7
% R
% Ser:
0
7
0
0
7
0
0
7
0
14
0
60
7
0
7
% S
% Thr:
7
0
7
67
0
0
0
7
60
7
7
0
54
0
0
% T
% Val:
0
0
0
0
0
0
0
0
14
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
7
7
67
0
14
0
20
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _