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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL1
All Species:
52.42
Human Site:
Y761
Identified Species:
82.38
UniProt:
Q13616
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13616
NP_003583.2
776
89679
Y761
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Chimpanzee
Pan troglodytes
XP_001165296
760
88111
Y745
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848402
776
89643
Y761
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9WTX6
776
89673
Y761
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Rat
Rattus norvegicus
Q9JJ31
780
90872
Y765
E
W
L
I
E
H
K
Y
I
R
R
D
E
A
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505554
776
89705
Y761
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Chicken
Gallus gallus
XP_418878
774
89674
Y759
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Frog
Xenopus laevis
Q6DE95
768
88933
Y753
E
G
L
I
E
R
E
Y
L
A
R
T
P
E
D
Zebra Danio
Brachydanio rerio
NP_955953
777
90010
Y762
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
Y759
D
I
L
I
E
K
E
Y
L
E
R
M
E
G
H
Honey Bee
Apis mellifera
XP_394044
777
89569
Y762
D
I
L
I
E
K
E
Y
L
E
R
T
E
G
Q
Nematode Worm
Caenorhab. elegans
Q17389
780
89509
Y765
G
S
L
I
E
K
E
Y
M
L
R
T
E
G
Q
Sea Urchin
Strong. purpuratus
XP_794360
770
89058
Y755
D
I
L
I
E
K
E
Y
L
E
R
V
D
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
Y723
E
D
L
I
T
R
D
Y
L
E
R
D
K
E
N
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
G800
I
D
S
L
I
Q
K
G
Y
L
Q
R
G
D
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
N.A.
99.7
N.A.
99.8
31.5
N.A.
99.7
97
31.8
96.5
N.A.
63.6
78.2
46.9
81.7
Protein Similarity:
100
97.9
N.A.
99.7
N.A.
99.8
53.4
N.A.
99.8
98
54.5
97.6
N.A.
77.9
87.9
65.5
91.2
P-Site Identity:
100
100
N.A.
100
N.A.
100
33.3
N.A.
100
100
46.6
100
N.A.
80
80
53.3
100
P-Site Similarity:
100
100
N.A.
100
N.A.
100
66.6
N.A.
100
100
66.6
100
N.A.
93.3
93.3
73.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.9
33.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.5
55
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
67
14
0
0
0
0
7
0
0
0
0
14
54
7
20
% D
% Glu:
20
0
0
0
87
0
80
0
0
74
0
0
27
14
54
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
7
0
0
0
0
0
7
0
0
0
0
7
74
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
67
0
94
7
0
0
0
7
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
74
14
0
0
0
0
0
7
0
0
% K
% Leu:
0
0
94
7
0
0
0
0
80
14
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
0
7
0
0
0
0
7
0
0
0
14
% Q
% Arg:
0
0
0
0
0
14
0
0
0
7
94
7
0
0
0
% R
% Ser:
0
7
7
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
20
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
54
0
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
94
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _