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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL2
All Species:
22.73
Human Site:
S374
Identified Species:
41.67
UniProt:
Q13617
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13617
NP_003582.2
745
86983
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Chimpanzee
Pan troglodytes
XP_507738
829
95741
S458
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535140
745
86988
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4H8
745
86858
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Rat
Rattus norvegicus
Q9JJ31
780
90872
G393
E
L
P
L
K
Q
K
G
V
G
L
K
T
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508563
745
87017
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Chicken
Gallus gallus
NP_001026141
688
80276
M299
I
H
E
C
Q
Q
R
M
V
A
D
H
L
Q
F
Frog
Xenopus laevis
Q6GPF3
768
88937
A371
R
L
F
K
Q
T
I
A
G
D
F
E
Y
F
L
Zebra Danio
Brachydanio rerio
XP_002666627
745
86977
S374
A
L
D
K
A
L
T
S
V
V
N
Y
R
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
N404
K
A
C
G
K
F
I
N
S
N
V
V
T
I
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17390
776
89707
V391
L
D
K
A
L
Q
G
V
V
N
S
K
E
P
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
E372
K
A
L
K
E
A
F
E
I
F
C
N
K
T
V
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
E420
G
A
F
I
N
I
N
E
F
A
L
P
A
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
N.A.
99.4
N.A.
97.3
28.9
N.A.
96.5
83.3
28.1
92.2
N.A.
33
N.A.
43
N.A.
Protein Similarity:
100
87.6
N.A.
99.5
N.A.
99.3
50.7
N.A.
98.6
86.4
51.5
96.9
N.A.
55.1
N.A.
64.1
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
20
N.A.
100
6.6
13.3
100
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
26.6
N.A.
100
33.3
20
100
N.A.
6.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.5
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
47
24
0
8
47
8
0
8
0
16
0
0
8
0
8
% A
% Cys:
0
0
8
8
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
8
47
0
0
0
0
0
0
8
8
0
0
0
0
% D
% Glu:
8
0
8
0
8
0
0
16
0
0
0
8
8
47
0
% E
% Phe:
0
0
16
0
0
8
8
0
8
8
8
0
0
8
8
% F
% Gly:
8
0
0
8
0
0
8
8
8
8
0
0
0
8
8
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
0
0
8
0
8
16
0
8
0
0
0
0
8
0
% I
% Lys:
16
0
8
62
16
0
8
0
0
0
0
16
8
0
0
% K
% Leu:
8
62
8
8
8
47
0
0
0
0
16
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
8
8
0
16
47
8
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
0
0
0
8
0
8
54
% P
% Gln:
0
0
0
0
16
24
0
0
0
0
0
0
0
16
0
% Q
% Arg:
8
0
0
0
0
0
8
0
0
0
0
0
47
0
0
% R
% Ser:
0
0
0
0
0
0
0
47
8
0
8
0
0
0
8
% S
% Thr:
0
0
0
0
0
8
47
0
0
0
0
0
16
8
0
% T
% Val:
0
0
0
0
0
0
0
8
70
47
8
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
47
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _