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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL2
All Species:
40.91
Human Site:
S448
Identified Species:
75
UniProt:
Q13617
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13617
NP_003582.2
745
86983
S448
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Chimpanzee
Pan troglodytes
XP_507738
829
95741
S532
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535140
745
86988
S448
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4H8
745
86858
S448
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Rat
Rattus norvegicus
Q9JJ31
780
90872
S467
R
R
L
I
L
D
I
S
A
D
S
E
I
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508563
745
87017
S448
K
R
L
I
H
G
L
S
M
S
M
D
S
E
E
Chicken
Gallus gallus
NP_001026141
688
80276
L373
T
Q
F
V
E
S
V
L
E
V
H
S
K
L
V
Frog
Xenopus laevis
Q6GPF3
768
88937
S445
R
R
L
L
T
N
K
S
V
S
D
D
S
E
K
Zebra Danio
Brachydanio rerio
XP_002666627
745
86977
S448
K
R
L
I
H
G
L
S
L
S
M
D
S
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
S478
K
R
L
V
N
H
T
S
A
S
D
D
A
E
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17390
776
89707
S465
N
R
L
I
A
S
T
S
I
S
M
D
A
E
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
S446
R
R
L
L
F
D
R
S
A
N
D
D
H
E
R
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
S494
K
R
L
I
H
G
T
S
T
S
A
E
D
E
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
N.A.
99.4
N.A.
97.3
28.9
N.A.
96.5
83.3
28.1
92.2
N.A.
33
N.A.
43
N.A.
Protein Similarity:
100
87.6
N.A.
99.5
N.A.
99.3
50.7
N.A.
98.6
86.4
51.5
96.9
N.A.
55.1
N.A.
64.1
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
40
N.A.
100
0
46.6
93.3
N.A.
46.6
N.A.
60
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
60
N.A.
100
20
73.3
100
N.A.
66.6
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.5
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
33.3
66.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
24
0
8
0
16
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
16
0
0
0
8
24
77
8
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
8
0
0
16
0
93
70
% E
% Phe:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
54
8
0
0
0
0
8
0
8
0
0
% H
% Ile:
0
0
0
70
0
0
8
0
8
0
0
0
8
0
0
% I
% Lys:
62
0
0
0
0
0
8
0
0
0
0
0
8
0
8
% K
% Leu:
0
0
93
16
8
0
47
8
8
0
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
39
0
54
0
0
0
0
% M
% Asn:
8
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
24
93
0
0
0
0
8
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
16
0
93
0
77
8
8
54
0
0
% S
% Thr:
8
0
0
0
8
0
24
0
8
0
0
0
0
0
0
% T
% Val:
0
0
0
16
0
0
8
0
8
8
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _