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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL2
All Species:
39.09
Human Site:
Y235
Identified Species:
71.67
UniProt:
Q13617
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13617
NP_003582.2
745
86983
Y235
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Chimpanzee
Pan troglodytes
XP_507738
829
95741
Y337
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535140
745
86988
Y235
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9D4H8
745
86858
Y235
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Rat
Rattus norvegicus
Q9JJ31
780
90872
Y230
Q
Q
N
G
V
Q
N
Y
M
K
Y
A
D
A
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508563
745
87017
Y235
Q
E
S
H
C
S
Q
Y
M
E
K
V
L
G
R
Chicken
Gallus gallus
NP_001026141
688
80276
T190
K
H
F
C
F
N
T
T
G
S
R
Q
D
L
E
Frog
Xenopus laevis
Q6GPF3
768
88937
Y233
A
E
N
S
A
S
V
Y
I
K
K
V
E
A
R
Zebra Danio
Brachydanio rerio
XP_002666627
745
86977
Y235
Q
E
S
N
C
S
Q
Y
M
E
K
V
L
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
Y251
S
T
N
T
V
T
E
Y
L
K
H
V
E
N
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q17390
776
89707
Y251
T
D
L
S
C
S
E
Y
M
E
Q
V
I
V
L
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
Y220
Q
E
D
S
C
P
D
Y
M
L
K
S
E
E
C
Baker's Yeast
Sacchar. cerevisiae
Q12018
815
93926
Y252
E
K
H
S
V
T
E
Y
I
F
E
A
H
E
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
N.A.
99.4
N.A.
97.3
28.9
N.A.
96.5
83.3
28.1
92.2
N.A.
33
N.A.
43
N.A.
Protein Similarity:
100
87.6
N.A.
99.5
N.A.
99.3
50.7
N.A.
98.6
86.4
51.5
96.9
N.A.
55.1
N.A.
64.1
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
20
N.A.
93.3
0
40
100
N.A.
20
N.A.
40
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
46.6
N.A.
100
20
66.6
100
N.A.
53.3
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.5
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
0
16
0
16
0
% A
% Cys:
0
0
0
8
62
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
8
8
0
0
0
8
0
0
0
0
0
16
0
0
% D
% Glu:
8
62
0
0
0
0
24
0
0
54
8
0
24
16
8
% E
% Phe:
0
0
8
0
8
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
8
0
0
0
0
47
0
% G
% His:
0
8
8
8
0
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
16
0
0
0
8
0
8
% I
% Lys:
8
8
0
0
0
0
0
0
0
24
62
0
0
0
8
% K
% Leu:
0
0
8
0
0
0
0
0
8
8
0
0
47
8
8
% L
% Met:
0
0
0
0
0
0
0
0
70
0
0
0
0
0
0
% M
% Asn:
0
0
24
39
0
8
8
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
62
8
0
0
0
8
47
0
0
0
8
8
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
62
% R
% Ser:
8
0
47
31
0
62
0
0
0
8
0
8
0
0
0
% S
% Thr:
8
8
0
8
0
16
8
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
24
0
8
0
0
0
0
70
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _