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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL2 All Species: 22.73
Human Site: Y558 Identified Species: 41.67
UniProt: Q13617 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13617 NP_003582.2 745 86983 Y558 R K L T W L H Y L C T G E V K
Chimpanzee Pan troglodytes XP_507738 829 95741 Y642 R K L T W L H Y L C T G E V K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535140 745 86988 Y558 R K L T W L H Y L C T G E V K
Cat Felis silvestris
Mouse Mus musculus Q9D4H8 745 86858 Y558 R K L T W L H Y L C T G E V K
Rat Rattus norvegicus Q9JJ31 780 90872 L576 R K L H W H H L M S N G I I T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508563 745 87017 Y558 R K L T W L H Y L C T G E V K
Chicken Gallus gallus NP_001026141 688 80276 K491 E A M I N K L K Q A C G Y E F
Frog Xenopus laevis Q6GPF3 768 88937 V575 K K E D G S E V G V G G A Q V
Zebra Danio Brachydanio rerio XP_002666627 745 86977 Y558 R K L T W L H Y L C T G E V K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 K587 N W L Y Q M C K G E L I M N V
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17390 776 89707 N589 R K L T W L F N M S Q G D V R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 G555 L T W I Y S L G T C H I N G K
Baker's Yeast Sacchar. cerevisiae Q12018 815 93926 R607 K W L W P L C R G E L K A D I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 87.4 N.A. 99.4 N.A. 97.3 28.9 N.A. 96.5 83.3 28.1 92.2 N.A. 33 N.A. 43 N.A.
Protein Similarity: 100 87.6 N.A. 99.5 N.A. 99.3 50.7 N.A. 98.6 86.4 51.5 96.9 N.A. 55.1 N.A. 64.1 N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 40 N.A. 100 6.6 13.3 100 N.A. 6.6 N.A. 53.3 N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 53.3 N.A. 100 13.3 20 100 N.A. 13.3 N.A. 73.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 28.5 26.5 N.A.
Protein Similarity: N.A. N.A. N.A. 52.3 46.6 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 0 0 0 8 0 0 16 0 0 % A
% Cys: 0 0 0 0 0 0 16 0 0 54 8 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 0 0 0 0 8 8 0 % D
% Glu: 8 0 8 0 0 0 8 0 0 16 0 0 47 8 0 % E
% Phe: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 0 8 0 0 8 24 0 8 77 0 8 0 % G
% His: 0 0 0 8 0 8 54 0 0 0 8 0 0 0 0 % H
% Ile: 0 0 0 16 0 0 0 0 0 0 0 16 8 8 8 % I
% Lys: 16 70 0 0 0 8 0 16 0 0 0 8 0 0 54 % K
% Leu: 8 0 77 0 0 62 16 8 47 0 16 0 0 0 0 % L
% Met: 0 0 8 0 0 8 0 0 16 0 0 0 8 0 0 % M
% Asn: 8 0 0 0 8 0 0 8 0 0 8 0 8 8 0 % N
% Pro: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 8 0 0 0 8 0 8 0 0 8 0 % Q
% Arg: 62 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % R
% Ser: 0 0 0 0 0 16 0 0 0 16 0 0 0 0 0 % S
% Thr: 0 8 0 54 0 0 0 0 8 0 47 0 0 0 8 % T
% Val: 0 0 0 0 0 0 0 8 0 8 0 0 0 54 16 % V
% Trp: 0 16 8 8 62 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 0 0 47 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _