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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL3 All Species: 45.76
Human Site: S447 Identified Species: 67.11
UniProt: Q13618 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13618 NP_003581.1 768 88930 S447 L L T N K S V S D D S E K N M
Chimpanzee Pan troglodytes XP_001167451 757 87889 S436 L L T N K S V S D D S E K N M
Rhesus Macaque Macaca mulatta XP_001109600 746 86448 S425 L L T N K S V S D D S E K N M
Dog Lupus familis XP_534586 746 86477 S425 L L T N K S V S D D S E K N M
Cat Felis silvestris
Mouse Mus musculus Q9JLV5 768 88930 S447 L L T N K S V S D D S E K N M
Rat Rattus norvegicus Q9JJ31 780 90872 S470 I L D I S A D S E I E E N M V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512511 642 74121 E335 M I S K L K T E C G C Q F T S
Chicken Gallus gallus XP_422620 768 88957 S447 L L T N K S V S D D S E K N M
Frog Xenopus laevis Q6DE95 768 88933 S447 L L T N K S V S D D S E K N M
Zebra Danio Brachydanio rerio NP_955985 766 89011 S445 L L T N K S V S D D S E K N M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 K463 E D K D V F Q K Y Y S K M L A
Honey Bee Apis mellifera XP_625079 767 89385 S445 L L L N K S V S D D S E K N M
Nematode Worm Caenorhab. elegans Q17391 777 90217 S453 L L L D K S C S D D V E K A L
Sea Urchin Strong. purpuratus XP_001178314 675 78472 S368 L L L N K S V S D D S E K N M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 F429 Y I S D K D L F A E F Y R K K
Baker's Yeast Sacchar. cerevisiae P53202 744 86097 G421 L D S T K L I G L L T E K D I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.1 96.8 N.A. 99.4 26.4 N.A. 83.1 99.6 98.5 95.9 N.A. 28.4 77.2 49.6 67
Protein Similarity: 100 98 97.1 96.8 N.A. 99.6 49.4 N.A. 83.3 99.7 99.2 98.3 N.A. 52.4 87.5 69.1 76.9
P-Site Identity: 100 100 100 100 N.A. 100 20 N.A. 0 100 100 100 N.A. 6.6 93.3 60 93.3
P-Site Similarity: 100 100 100 100 N.A. 100 46.6 N.A. 26.6 100 100 100 N.A. 20 93.3 73.3 93.3
Percent
Protein Identity: N.A. N.A. N.A. 31.3 26.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.5 46.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 46.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 0 0 7 0 0 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 7 0 7 0 7 0 0 0 0 % C
% Asp: 0 13 7 19 0 7 7 0 69 69 0 0 0 7 0 % D
% Glu: 7 0 0 0 0 0 0 7 7 7 7 82 0 0 0 % E
% Phe: 0 0 0 0 0 7 0 7 0 0 7 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 7 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 13 0 7 0 0 7 0 0 7 0 0 0 0 7 % I
% Lys: 0 0 7 7 82 7 0 7 0 0 0 7 75 7 7 % K
% Leu: 75 75 19 0 7 7 7 0 7 7 0 0 0 7 7 % L
% Met: 7 0 0 0 0 0 0 0 0 0 0 0 7 7 63 % M
% Asn: 0 0 0 63 0 0 0 0 0 0 0 0 7 63 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 7 0 0 0 0 7 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % R
% Ser: 0 0 19 0 7 69 0 75 0 0 69 0 0 0 7 % S
% Thr: 0 0 50 7 0 0 7 0 0 0 7 0 0 7 0 % T
% Val: 0 0 0 0 7 0 63 0 0 0 7 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 7 0 0 0 0 0 0 0 7 7 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _