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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CUL3
All Species:
40.61
Human Site:
S478
Identified Species:
59.56
UniProt:
Q13618
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13618
NP_003581.1
768
88930
S478
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Chimpanzee
Pan troglodytes
XP_001167451
757
87889
S467
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Rhesus Macaque
Macaca mulatta
XP_001109600
746
86448
S456
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Dog
Lupus familis
XP_534586
746
86477
S456
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9JLV5
768
88930
S478
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Rat
Rattus norvegicus
Q9JJ31
780
90872
K501
A
R
M
F
Q
D
I
K
V
S
E
D
L
N
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512511
642
74121
Q366
D
E
F
R
Q
H
L
Q
S
T
G
V
S
L
G
Chicken
Gallus gallus
XP_422620
768
88957
S478
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Frog
Xenopus laevis
Q6DE95
768
88933
S478
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Zebra Danio
Brachydanio rerio
NP_955985
766
89011
S476
E
G
M
F
R
D
M
S
I
S
N
T
T
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24311
774
89493
T494
M
I
S
K
L
K
Q
T
C
G
Y
E
Y
T
V
Honey Bee
Apis mellifera
XP_625079
767
89385
T476
E
G
M
F
K
D
I
T
V
S
N
T
I
M
D
Nematode Worm
Caenorhab. elegans
Q17391
777
90217
E484
E
N
M
F
R
D
K
E
L
W
L
T
L
A
T
Sea Urchin
Strong. purpuratus
XP_001178314
675
78472
T399
E
G
M
F
K
D
M
T
L
S
N
T
F
M
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94AH6
738
86284
K460
R
S
I
L
T
K
L
K
Q
Q
C
G
G
Q
F
Baker's Yeast
Sacchar. cerevisiae
P53202
744
86097
K452
R
S
L
V
E
I
E
K
W
M
V
Q
M
I
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.1
96.8
N.A.
99.4
26.4
N.A.
83.1
99.6
98.5
95.9
N.A.
28.4
77.2
49.6
67
Protein Similarity:
100
98
97.1
96.8
N.A.
99.6
49.4
N.A.
83.3
99.7
99.2
98.3
N.A.
52.4
87.5
69.1
76.9
P-Site Identity:
100
100
100
100
N.A.
100
26.6
N.A.
0
100
100
100
N.A.
0
66.6
40
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
46.6
N.A.
40
100
100
100
N.A.
6.6
93.3
46.6
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
26.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
54.5
46.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
7
0
7
0
0
0
0
% C
% Asp:
7
0
0
0
0
75
0
0
0
0
0
7
0
0
63
% D
% Glu:
69
7
0
0
7
0
7
7
0
0
7
7
0
0
0
% E
% Phe:
0
0
7
75
0
0
0
0
0
0
0
0
7
0
7
% F
% Gly:
0
63
0
0
0
0
0
0
0
7
7
7
7
0
7
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
7
0
0
7
13
0
50
0
0
0
7
7
0
% I
% Lys:
0
0
0
7
13
13
7
19
0
0
0
0
0
0
7
% K
% Leu:
0
0
7
7
7
0
13
0
13
0
7
0
13
7
0
% L
% Met:
7
0
75
0
0
0
57
0
0
7
0
0
7
63
0
% M
% Asn:
0
7
0
0
0
0
0
0
0
0
63
0
0
7
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
13
0
7
7
7
7
0
7
0
7
7
% Q
% Arg:
13
7
0
7
57
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
13
7
0
0
0
0
50
7
69
0
0
7
0
0
% S
% Thr:
0
0
0
0
7
0
0
19
0
7
0
69
50
7
7
% T
% Val:
0
0
0
7
0
0
0
0
13
0
7
7
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
7
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _