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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL3 All Species: 43.94
Human Site: S737 Identified Species: 64.44
UniProt: Q13618 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13618 NP_003581.1 768 88930 S737 L K A R F L P S P V V I K K R
Chimpanzee Pan troglodytes XP_001167451 757 87889 S726 L K A R F L P S P V V I K K R
Rhesus Macaque Macaca mulatta XP_001109600 746 86448 S715 L K A R F L P S P V V I K K R
Dog Lupus familis XP_534586 746 86477 S715 L K A R F L P S P V V I K K R
Cat Felis silvestris
Mouse Mus musculus Q9JLV5 768 88930 S737 L K A R F L P S P V V I K K R
Rat Rattus norvegicus Q9JJ31 780 90872 Q749 L K N M F L P Q K K M I K E Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512511 642 74121 V613 A R F L P S P V V I K K R I E
Chicken Gallus gallus XP_422620 768 88957 S737 L K A R F L P S P V V I K K R
Frog Xenopus laevis Q6DE95 768 88933 S737 L K A R F L P S P V V I K K R
Zebra Danio Brachydanio rerio NP_955985 766 89011 S735 L R A R F L P S P V V I K K R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 K743 L S T R F K P K V P V I K K C
Honey Bee Apis mellifera XP_625079 767 89385 S736 L R G R F L P S P V I I K K R
Nematode Worm Caenorhab. elegans Q17391 777 90217 S746 L R H R F M P S P I I I K Q R
Sea Urchin Strong. purpuratus XP_001178314 675 78472 S646 E V T E Q L K S R F L P S P V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 I708 S R M F K P D I K A I K K R M
Baker's Yeast Sacchar. cerevisiae P53202 744 86097 T713 T Q S R L S L T P S I L K R S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.1 96.8 N.A. 99.4 26.4 N.A. 83.1 99.6 98.5 95.9 N.A. 28.4 77.2 49.6 67
Protein Similarity: 100 98 97.1 96.8 N.A. 99.6 49.4 N.A. 83.3 99.7 99.2 98.3 N.A. 52.4 87.5 69.1 76.9
P-Site Identity: 100 100 100 100 N.A. 100 46.6 N.A. 6.6 100 100 93.3 N.A. 53.3 80 60 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 66.6 N.A. 26.6 100 100 100 N.A. 53.3 93.3 93.3 20
Percent
Protein Identity: N.A. N.A. N.A. 31.3 26.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.5 46.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 50 0 0 0 0 0 0 7 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 0 7 0 0 0 0 0 0 0 0 0 7 7 % E
% Phe: 0 0 7 7 75 0 0 0 0 7 0 0 0 0 0 % F
% Gly: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 7 0 13 25 75 0 7 0 % I
% Lys: 0 50 0 0 7 7 7 7 13 7 7 13 88 63 0 % K
% Leu: 75 0 0 7 7 69 7 0 0 0 7 7 0 0 0 % L
% Met: 0 0 7 7 0 7 0 0 0 0 7 0 0 0 7 % M
% Asn: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 7 7 82 0 69 7 0 7 0 7 0 % P
% Gln: 0 7 0 0 7 0 0 7 0 0 0 0 0 7 7 % Q
% Arg: 0 32 0 75 0 0 0 0 7 0 0 0 7 13 63 % R
% Ser: 7 7 7 0 0 13 0 69 0 7 0 0 7 0 7 % S
% Thr: 7 0 13 0 0 0 0 7 0 0 0 0 0 0 0 % T
% Val: 0 7 0 0 0 0 0 7 13 57 57 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _