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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL3 All Species: 13.33
Human Site: T14 Identified Species: 19.56
UniProt: Q13618 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13618 NP_003581.1 768 88930 T14 G T G S R K D T K M R I R A F
Chimpanzee Pan troglodytes XP_001167451 757 87889 M14 L R Y T E M T M D E K Y V N S
Rhesus Macaque Macaca mulatta XP_001109600 746 86448 L14 Y V N S I W D L L K N A I Q E
Dog Lupus familis XP_534586 746 86477 L14 Y V N S I W D L L K N A I Q E
Cat Felis silvestris
Mouse Mus musculus Q9JLV5 768 88930 T14 G T G S R K D T K M R I R A F
Rat Rattus norvegicus Q9JJ31 780 90872 E16 N K G S L Q F E D K W D F M R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512511 642 74121
Chicken Gallus gallus XP_422620 768 88957 T14 G T G S R K D T K M R I R A F
Frog Xenopus laevis Q6DE95 768 88933 T14 S T G S R K D T K M R I R A F
Zebra Danio Brachydanio rerio NP_955985 766 89011 M14 G T K K D T K M R I R A F P M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 N15 Q T T Q K L V N L D D I W S E
Honey Bee Apis mellifera XP_625079 767 89385 R14 L K K E S K M R I R A F P T T
Nematode Worm Caenorhab. elegans Q17391 777 90217 R14 N G G Q Q K M R I R P F M A T
Sea Urchin Strong. purpuratus XP_001178314 675 78472
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 G18 G W D Y M Q T G I T K L K R I
Baker's Yeast Sacchar. cerevisiae P53202 744 86097 L15 K I S V P E K L G L S E E S F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.1 96.8 N.A. 99.4 26.4 N.A. 83.1 99.6 98.5 95.9 N.A. 28.4 77.2 49.6 67
Protein Similarity: 100 98 97.1 96.8 N.A. 99.6 49.4 N.A. 83.3 99.7 99.2 98.3 N.A. 52.4 87.5 69.1 76.9
P-Site Identity: 100 0 13.3 13.3 N.A. 100 13.3 N.A. 0 100 93.3 20 N.A. 13.3 6.6 20 0
P-Site Similarity: 100 13.3 13.3 13.3 N.A. 100 20 N.A. 0 100 93.3 33.3 N.A. 26.6 6.6 26.6 0
Percent
Protein Identity: N.A. N.A. N.A. 31.3 26.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.5 46.8 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 7 19 0 32 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 7 0 7 0 38 0 13 7 7 7 0 0 0 % D
% Glu: 0 0 0 7 7 7 0 7 0 7 0 7 7 0 19 % E
% Phe: 0 0 0 0 0 0 7 0 0 0 0 13 13 0 32 % F
% Gly: 32 7 38 0 0 0 0 7 7 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 13 0 0 0 19 7 0 32 13 0 7 % I
% Lys: 7 13 13 7 7 38 13 0 25 19 13 0 7 0 0 % K
% Leu: 13 0 0 0 7 7 0 19 19 7 0 7 0 0 0 % L
% Met: 0 0 0 0 7 7 13 13 0 25 0 0 7 7 7 % M
% Asn: 13 0 13 0 0 0 0 7 0 0 13 0 0 7 0 % N
% Pro: 0 0 0 0 7 0 0 0 0 0 7 0 7 7 0 % P
% Gln: 7 0 0 13 7 13 0 0 0 0 0 0 0 13 0 % Q
% Arg: 0 7 0 0 25 0 0 13 7 13 32 0 25 7 7 % R
% Ser: 7 0 7 44 7 0 0 0 0 0 7 0 0 13 7 % S
% Thr: 0 38 7 7 0 7 13 25 0 7 0 0 0 7 13 % T
% Val: 0 13 0 7 0 0 7 0 0 0 0 0 7 0 0 % V
% Trp: 0 7 0 0 0 13 0 0 0 0 7 0 7 0 0 % W
% Tyr: 13 0 7 7 0 0 0 0 0 0 0 7 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _