Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL3 All Species: 31.82
Human Site: T645 Identified Species: 46.67
UniProt: Q13618 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13618 NP_003581.1 768 88930 T645 K P T Q R V L T K E P K S K E
Chimpanzee Pan troglodytes XP_001167451 757 87889 T634 K P T Q R V L T K E P K S K E
Rhesus Macaque Macaca mulatta XP_001109600 746 86448 T623 K P T Q R V L T K E P K S K E
Dog Lupus familis XP_534586 746 86477 T623 K P T Q R V L T K E P K S K E
Cat Felis silvestris
Mouse Mus musculus Q9JLV5 768 88930 T645 K P T Q R V L T K E P K S K E
Rat Rattus norvegicus Q9JJ31 780 90872 G663 S P K D F T E G T L F S V N Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512511 642 74121 E528 E P K S K E I E N G H I F T V
Chicken Gallus gallus XP_422620 768 88957 T645 K P T Q R V L T K E P K S K E
Frog Xenopus laevis Q6DE95 768 88933 T645 K P T Q R V L T K E P K S K E
Zebra Danio Brachydanio rerio NP_955985 766 89011 T643 K P T Q R V L T K E P K S K E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 N657 K V L T S S D N E N S L T P E
Honey Bee Apis mellifera XP_625079 767 89385 L645 K A T Q R V L L K H P R T K E
Nematode Worm Caenorhab. elegans Q17391 777 90217 V654 K A S Q R I L V R K N K G K D
Sea Urchin Strong. purpuratus XP_001178314 675 78472 K561 P T Q R I L V K E P K G K E I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 E623 K Y K I L L K E P N T K T V S
Baker's Yeast Sacchar. cerevisiae P53202 744 86097 K623 P R C K I L K K S S S S G N M
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.9 97.1 96.8 N.A. 99.4 26.4 N.A. 83.1 99.6 98.5 95.9 N.A. 28.4 77.2 49.6 67
Protein Similarity: 100 98 97.1 96.8 N.A. 99.6 49.4 N.A. 83.3 99.7 99.2 98.3 N.A. 52.4 87.5 69.1 76.9
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 6.6 100 100 100 N.A. 13.3 66.6 40 0
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 26.6 100 100 100 N.A. 26.6 80 73.3 33.3
Percent
Protein Identity: N.A. N.A. N.A. 31.3 26.1 N.A.
Protein Similarity: N.A. N.A. N.A. 54.5 46.8 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 13 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 7 0 0 0 0 0 0 0 7 % D
% Glu: 7 0 0 0 0 7 7 13 13 50 0 0 0 7 63 % E
% Phe: 0 0 0 0 7 0 0 0 0 0 7 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 7 0 7 0 7 13 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 7 7 0 0 0 0 % H
% Ile: 0 0 0 7 13 7 7 0 0 0 0 7 0 0 7 % I
% Lys: 75 0 19 7 7 0 13 13 57 7 7 63 7 63 0 % K
% Leu: 0 0 7 0 7 19 63 7 0 7 0 7 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % M
% Asn: 0 0 0 0 0 0 0 7 7 13 7 0 0 13 0 % N
% Pro: 13 63 0 0 0 0 0 0 7 7 57 0 0 7 0 % P
% Gln: 0 0 7 63 0 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 0 7 0 7 63 0 0 0 7 0 0 7 0 0 0 % R
% Ser: 7 0 7 7 7 7 0 0 7 7 13 13 50 0 7 % S
% Thr: 0 7 57 7 0 7 0 50 7 0 7 0 19 7 0 % T
% Val: 0 7 0 0 0 57 7 7 0 0 0 0 7 7 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _