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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CUL4A All Species: 34.85
Human Site: Y58 Identified Species: 58.97
UniProt: Q13619 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13619 NP_001008895.1 759 87680 Y58 R P R L P D N Y T Q D T W R K
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001086195 913 103935 Y212 K P K L P E N Y T D E T W Q K
Dog Lupus familis XP_849542 856 98255 Y155 R P R L P D N Y T Q D T W Q K
Cat Felis silvestris
Mouse Mus musculus Q3TCH7 759 87735 Y58 R P R L P D N Y T Q D T W R K
Rat Rattus norvegicus Q9JJ31 780 90872 S82 Q A Q A R V L S H Q D D T A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515026 756 87763 Y55 R P K L P D N Y T Q D T W Q Q
Chicken Gallus gallus XP_420335 883 101241 Y182 K P K L P E N Y T D E T W Q K
Frog Xenopus laevis Q6DE95 768 88933 Y74 H K H G E K L Y T G L R E V V
Zebra Danio Brachydanio rerio NP_001116316 864 99408 Y163 K P K L P E N Y T N E T W Q K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24311 774 89493 S57 Y D Y C T S V S A A P S G R S
Honey Bee Apis mellifera XP_392800 814 93580 Y110 K P K L P E N Y Q E Q T W E K
Nematode Worm Caenorhab. elegans Q17391 777 90217 H81 L K D V I Q D H M A S V R I R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q94AH6 738 86284 Y58 T Q K P P H D Y S Q Q L Y D K
Baker's Yeast Sacchar. cerevisiae Q12018 815 93926 F69 K S R S S G H F S T D S R T G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 69.5 82.7 N.A. 95.1 26.9 N.A. 89.1 72.7 39.4 73.6 N.A. 29.5 64.7 35.2 N.A.
Protein Similarity: 100 N.A. 76.5 85.2 N.A. 97.2 47.9 N.A. 95.2 79.2 58.9 80.2 N.A. 47.4 77 55.4 N.A.
P-Site Identity: 100 N.A. 60 93.3 N.A. 100 13.3 N.A. 80 60 13.3 60 N.A. 6.6 53.3 0 N.A.
P-Site Similarity: 100 N.A. 93.3 100 N.A. 100 26.6 N.A. 100 93.3 13.3 93.3 N.A. 13.3 80 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 35.1 22.8 N.A.
Protein Similarity: N.A. N.A. N.A. 57.1 43.1 N.A.
P-Site Identity: N.A. N.A. N.A. 26.6 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 8 0 0 0 0 8 15 0 0 0 8 0 % A
% Cys: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 0 29 15 0 0 15 43 8 0 8 0 % D
% Glu: 0 0 0 0 8 29 0 0 0 8 22 0 8 8 0 % E
% Phe: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 8 0 8 0 0 0 8 0 0 8 0 8 % G
% His: 8 0 8 0 0 8 8 8 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 36 15 43 0 0 8 0 0 0 0 0 0 0 0 58 % K
% Leu: 8 0 0 58 0 0 15 0 0 0 8 8 0 0 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 58 0 0 8 0 0 0 0 0 % N
% Pro: 0 58 0 8 65 0 0 0 0 0 8 0 0 0 0 % P
% Gln: 8 8 8 0 0 8 0 0 8 43 15 0 0 36 8 % Q
% Arg: 29 0 29 0 8 0 0 0 0 0 0 8 15 22 8 % R
% Ser: 0 8 0 8 8 8 0 15 15 0 8 15 0 0 8 % S
% Thr: 8 0 0 0 8 0 0 0 58 8 0 58 8 8 0 % T
% Val: 0 0 0 8 0 8 8 0 0 0 0 8 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 58 0 0 % W
% Tyr: 8 0 8 0 0 0 0 72 0 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _