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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTCH1
All Species:
6.97
Human Site:
T1404
Identified Species:
17.04
UniProt:
Q13635
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13635
NP_000255.2
1447
160545
T1404
L
C
P
G
Y
P
E
T
D
H
G
L
F
E
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111868
801
89943
D769
G
S
R
D
K
P
I
D
I
S
Q
V
P
Q
L
Dog
Lupus familis
XP_539636
1126
122022
H1094
P
L
P
G
A
Y
I
H
P
A
S
D
E
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61115
1434
159255
T1391
G
Y
E
S
Y
P
E
T
D
H
G
V
F
E
D
Rat
Rattus norvegicus
NP_446018
1434
159240
T1391
G
Y
E
S
Y
P
E
T
D
H
G
V
F
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90693
1442
160559
D1399
S
C
E
E
Y
N
E
D
D
R
G
M
F
E
D
Frog
Xenopus laevis
NP_001082082
1418
158209
F1380
H
E
N
D
H
G
H
F
E
D
P
H
V
P
I
Zebra Danio
Brachydanio rerio
Q98864
1220
135526
E1188
H
L
Q
S
P
S
P
E
P
M
P
P
P
M
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18502
1286
142812
T1253
P
E
V
T
V
E
T
T
H
S
D
S
N
T
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001194999
686
77000
A654
R
E
R
R
V
T
F
A
L
E
H
T
F
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53
44.7
N.A.
95.4
95.3
N.A.
N.A.
88.2
79.4
54.5
N.A.
36.7
N.A.
N.A.
22.6
Protein Similarity:
100
N.A.
53.5
58.8
N.A.
96.8
96.8
N.A.
N.A.
92.8
85.6
66.9
N.A.
55.3
N.A.
N.A.
32.2
P-Site Identity:
100
N.A.
6.6
13.3
N.A.
66.6
66.6
N.A.
N.A.
53.3
0
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
N.A.
20
13.3
N.A.
73.3
73.3
N.A.
N.A.
60
13.3
6.6
N.A.
6.6
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
10
0
10
0
0
0
0
0
% A
% Cys:
0
20
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
20
0
0
0
20
40
10
10
10
0
0
40
% D
% Glu:
0
30
30
10
0
10
40
10
10
10
0
0
10
40
0
% E
% Phe:
0
0
0
0
0
0
10
10
0
0
0
0
50
0
0
% F
% Gly:
30
0
0
20
0
10
0
0
0
0
40
0
0
0
0
% G
% His:
20
0
0
0
10
0
10
10
10
30
10
10
0
0
0
% H
% Ile:
0
0
0
0
0
0
20
0
10
0
0
0
0
0
10
% I
% Lys:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
20
0
0
0
0
0
0
10
0
0
10
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
10
0
10
0
% M
% Asn:
0
0
10
0
0
10
0
0
0
0
0
0
10
0
10
% N
% Pro:
20
0
20
0
10
40
10
0
20
0
20
10
20
20
10
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
10
0
0
10
0
% Q
% Arg:
10
0
20
10
0
0
0
0
0
10
0
0
0
0
0
% R
% Ser:
10
10
0
30
0
10
0
0
0
20
10
10
0
10
0
% S
% Thr:
0
0
0
10
0
10
10
40
0
0
0
10
0
10
20
% T
% Val:
0
0
10
0
20
0
0
0
0
0
0
30
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
20
0
0
40
10
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _