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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTCH1
All Species:
14.85
Human Site:
Y1241
Identified Species:
36.3
UniProt:
Q13635
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13635
NP_000255.2
1447
160545
Y1241
L
S
E
E
L
R
H
Y
E
A
Q
Q
G
A
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111868
801
89943
I625
Q
P
V
T
V
V
V
I
F
L
F
L
G
L
L
Dog
Lupus familis
XP_539636
1126
122022
F951
A
Y
P
S
G
S
P
F
L
F
W
E
Q
Y
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61115
1434
159255
Y1227
I
S
E
E
L
R
Q
Y
E
A
Q
Q
G
A
G
Rat
Rattus norvegicus
NP_446018
1434
159240
Y1227
I
S
E
E
L
R
H
Y
E
A
Q
Q
G
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90693
1442
160559
Y1240
I
S
E
E
L
H
H
Y
E
A
T
Q
S
P
G
Frog
Xenopus laevis
NP_001082082
1418
158209
Y1229
I
S
E
E
L
H
Q
Y
N
S
Q
Q
C
S
A
Zebra Danio
Brachydanio rerio
Q98864
1220
135526
I1045
N
P
W
T
A
G
V
I
V
F
I
L
P
M
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18502
1286
142812
A1110
L
S
M
V
G
P
E
A
E
L
V
P
L
E
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001194999
686
77000
P511
P
L
N
Y
T
Q
L
P
F
Y
L
N
N
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53
44.7
N.A.
95.4
95.3
N.A.
N.A.
88.2
79.4
54.5
N.A.
36.7
N.A.
N.A.
22.6
Protein Similarity:
100
N.A.
53.5
58.8
N.A.
96.8
96.8
N.A.
N.A.
92.8
85.6
66.9
N.A.
55.3
N.A.
N.A.
32.2
P-Site Identity:
100
N.A.
6.6
0
N.A.
86.6
86.6
N.A.
N.A.
66.6
46.6
0
N.A.
20
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
13.3
13.3
N.A.
93.3
93.3
N.A.
N.A.
73.3
66.6
0
N.A.
20
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
10
0
0
10
0
40
0
0
0
20
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
50
50
0
0
10
0
50
0
0
10
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
10
20
20
10
0
0
0
0
% F
% Gly:
0
0
0
0
20
10
0
0
0
0
0
0
40
0
40
% G
% His:
0
0
0
0
0
20
30
0
0
0
0
0
0
0
10
% H
% Ile:
40
0
0
0
0
0
0
20
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
20
10
0
0
50
0
10
0
10
20
10
20
10
20
20
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
0
0
10
10
% M
% Asn:
10
0
10
0
0
0
0
0
10
0
0
10
10
0
10
% N
% Pro:
10
20
10
0
0
10
10
10
0
0
0
10
10
10
0
% P
% Gln:
10
0
0
0
0
10
20
0
0
0
40
50
10
0
0
% Q
% Arg:
0
0
0
0
0
30
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
60
0
10
0
10
0
0
0
10
0
0
10
10
0
% S
% Thr:
0
0
0
20
10
0
0
0
0
0
10
0
0
10
0
% T
% Val:
0
0
10
10
10
10
20
0
10
0
10
0
0
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
10
0
10
0
0
0
50
0
10
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _