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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTCH1
All Species:
18.48
Human Site:
Y334
Identified Species:
45.19
UniProt:
Q13635
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13635
NP_000255.2
1447
160545
Y334
C
H
G
L
S
R
K
Y
M
H
W
Q
E
E
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111868
801
89943
Dog
Lupus familis
XP_539636
1126
122022
S91
Q
L
W
V
E
V
G
S
R
V
S
Q
E
L
H
Cat
Felis silvestris
Mouse
Mus musculus
Q61115
1434
159255
Y320
C
Q
G
L
S
R
K
Y
M
H
W
Q
E
E
L
Rat
Rattus norvegicus
NP_446018
1434
159240
Y320
C
Q
G
L
S
R
K
Y
M
H
W
Q
E
E
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90693
1442
160559
Y334
C
Y
G
L
S
R
K
Y
M
H
W
Q
E
E
L
Frog
Xenopus laevis
NP_001082082
1418
158209
Y324
C
Y
G
L
S
K
K
Y
M
H
W
Q
E
E
L
Zebra Danio
Brachydanio rerio
Q98864
1220
135526
K185
G
K
S
W
D
L
N
K
I
C
F
K
S
G
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18502
1286
142812
Q250
S
V
M
Q
Y
M
K
Q
K
M
S
E
E
K
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001194999
686
77000
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
53
44.7
N.A.
95.4
95.3
N.A.
N.A.
88.2
79.4
54.5
N.A.
36.7
N.A.
N.A.
22.6
Protein Similarity:
100
N.A.
53.5
58.8
N.A.
96.8
96.8
N.A.
N.A.
92.8
85.6
66.9
N.A.
55.3
N.A.
N.A.
32.2
P-Site Identity:
100
N.A.
0
13.3
N.A.
93.3
93.3
N.A.
N.A.
93.3
86.6
0
N.A.
13.3
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
0
20
N.A.
93.3
93.3
N.A.
N.A.
100
100
26.6
N.A.
33.3
N.A.
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
50
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
10
0
0
0
0
0
0
10
70
50
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
50
0
0
0
10
0
0
0
0
0
0
10
0
% G
% His:
0
10
0
0
0
0
0
0
0
50
0
0
0
0
10
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% I
% Lys:
0
10
0
0
0
10
60
10
10
0
0
10
0
10
0
% K
% Leu:
0
10
0
50
0
10
0
0
0
0
0
0
0
10
50
% L
% Met:
0
0
10
0
0
10
0
0
50
10
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
10
20
0
10
0
0
0
10
0
0
0
60
0
0
0
% Q
% Arg:
0
0
0
0
0
40
0
0
10
0
0
0
0
0
0
% R
% Ser:
10
0
10
0
50
0
0
10
0
0
20
0
10
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
10
0
10
0
10
0
0
0
10
0
0
0
0
10
% V
% Trp:
0
0
10
10
0
0
0
0
0
0
50
0
0
0
0
% W
% Tyr:
0
20
0
0
10
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _