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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACVR2B
All Species:
39.39
Human Site:
T274
Identified Species:
72.22
UniProt:
Q13705
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13705
NP_001097.2
512
57724
T274
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Chimpanzee
Pan troglodytes
XP_001171684
516
58074
T278
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Rhesus Macaque
Macaca mulatta
XP_001084713
521
58857
T283
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Dog
Lupus familis
XP_542709
507
57202
T269
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Cat
Felis silvestris
Mouse
Mus musculus
P27040
536
60524
T298
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Rat
Rattus norvegicus
P38445
513
57839
T275
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518896
634
71047
Q399
M
K
H
E
N
I
L
Q
F
I
G
A
E
K
R
Chicken
Gallus gallus
Q90670
512
57758
T274
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
I
Frog
Xenopus laevis
P27041
511
57917
T273
F
H
D
K
G
S
L
T
D
Y
L
K
G
N
L
Zebra Danio
Brachydanio rerio
NP_571285
509
57460
T272
F
H
E
R
G
S
L
T
D
Y
L
K
G
N
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395928
531
60411
C290
Y
H
E
K
G
S
L
C
D
Y
L
K
A
N
V
Nematode Worm
Caenorhab. elegans
P50488
744
84391
Y394
F
H
E
R
L
S
L
Y
E
L
L
K
N
N
V
Sea Urchin
Strong. purpuratus
XP_001194466
553
62367
C287
F
H
H
H
G
S
L
C
D
Y
L
K
A
N
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
95.9
97
N.A.
94.9
98.8
N.A.
41.6
89.4
82.8
79.3
N.A.
N.A.
51.4
25.8
49.7
Protein Similarity:
100
98.6
95.9
97.6
N.A.
94.9
99
N.A.
54.7
95.6
92.7
90
N.A.
N.A.
68.3
39.5
64
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
100
93.3
80
N.A.
N.A.
66.6
46.6
66.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
13.3
100
100
93.3
N.A.
N.A.
86.6
73.3
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
8
16
0
8
% A
% Cys:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% C
% Asp:
0
0
62
0
0
0
0
0
85
0
0
0
0
0
0
% D
% Glu:
0
0
24
8
0
0
0
0
8
0
0
0
8
0
0
% E
% Phe:
85
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
85
0
0
0
0
0
8
0
70
0
0
% G
% His:
0
93
16
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
54
% I
% Lys:
0
8
0
70
0
0
0
0
0
0
0
93
0
8
0
% K
% Leu:
0
0
0
0
8
0
100
0
0
8
93
0
0
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
0
8
93
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
0
0
0
0
0
93
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
70
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
8
0
85
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _