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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GTF2H2 All Species: 34.24
Human Site: S244 Identified Species: 57.95
UniProt: Q13888 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13888 NP_001506.1 395 44419 S244 S P P P A S S S S E C S L I R
Chimpanzee Pan troglodytes XP_001157963 395 44404 S244 S P P P A S S S S E C S L I R
Rhesus Macaque Macaca mulatta XP_001095474 395 44419 S244 S P P P A S S S S E C S L I R
Dog Lupus familis XP_535266 395 44483 S244 S P P P A S S S S E C S L I R
Cat Felis silvestris
Mouse Mus musculus Q9JIB4 396 44669 S244 S P P P A S S S S E C S L I R
Rat Rattus norvegicus A0JN27 396 44685 G244 S P P P A S S G S E C S L I R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512459 470 52108 S319 S P P P A S S S S E C S L I R
Chicken Gallus gallus
Frog Xenopus laevis NP_001085329 395 44828 S244 I P P P A S S S S E C S L I R
Zebra Danio Brachydanio rerio NP_963875 392 44051 S244 K P P P A S S S S E C S L I R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649427 438 48601 T247 D P P P A A K T Q H N S L I R
Honey Bee Apis mellifera XP_394997 405 45681 R245 D P P P A A T R L D A A L V K
Nematode Worm Caenorhab. elegans P34567 376 41593 D230 Y S V A L D P D H L Q L L F S
Sea Urchin Strong. purpuratus XP_782325 476 53839 N245 I P P P A R V N T E P S P I R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04673 461 52272 P309 N E A V T P L P V N K I N K G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 99.7 98.2 N.A. 96.9 96.4 N.A. 77.8 N.A. 84 81 N.A. 49 50.1 42.2 50.6
Protein Similarity: 100 100 100 98.9 N.A. 97.9 97.4 N.A. 80.8 N.A. 93.4 91.1 N.A. 65 69.1 62.5 63.4
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 100 N.A. 93.3 93.3 N.A. 53.3 33.3 6.6 53.3
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 100 N.A. 93.3 93.3 N.A. 66.6 73.3 6.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 8 86 15 0 0 0 0 8 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 65 0 0 0 0 % C
% Asp: 15 0 0 0 0 8 0 8 0 8 0 0 0 0 0 % D
% Glu: 0 8 0 0 0 0 0 0 0 72 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 8 % G
% His: 0 0 0 0 0 0 0 0 8 8 0 0 0 0 0 % H
% Ile: 15 0 0 0 0 0 0 0 0 0 0 8 0 79 0 % I
% Lys: 8 0 0 0 0 0 8 0 0 0 8 0 0 8 8 % K
% Leu: 0 0 0 0 8 0 8 0 8 8 0 8 86 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 0 0 0 0 8 0 8 8 0 8 0 0 % N
% Pro: 0 86 86 86 0 8 8 8 0 0 8 0 8 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 79 % R
% Ser: 50 8 0 0 0 65 65 58 65 0 0 79 0 0 8 % S
% Thr: 0 0 0 0 8 0 8 8 8 0 0 0 0 0 0 % T
% Val: 0 0 8 8 0 0 8 0 8 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _