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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GTF2H2 All Species: 39.39
Human Site: S245 Identified Species: 66.67
UniProt: Q13888 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13888 NP_001506.1 395 44419 S245 P P P A S S S S E C S L I R M
Chimpanzee Pan troglodytes XP_001157963 395 44404 S245 P P P A S S S S E C S L I R M
Rhesus Macaque Macaca mulatta XP_001095474 395 44419 S245 P P P A S S S S E C S L I R M
Dog Lupus familis XP_535266 395 44483 S245 P P P A S S S S E C S L I R M
Cat Felis silvestris
Mouse Mus musculus Q9JIB4 396 44669 S245 P P P A S S S S E C S L I R M
Rat Rattus norvegicus A0JN27 396 44685 S245 P P P A S S G S E C S L I R M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512459 470 52108 S320 P P P A S S S S E C S L I R M
Chicken Gallus gallus
Frog Xenopus laevis NP_001085329 395 44828 S245 P P P A S S S S E C S L I R M
Zebra Danio Brachydanio rerio NP_963875 392 44051 S245 P P P A S S S S E C S L I R M
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_649427 438 48601 Q248 P P P A A K T Q H N S L I R M
Honey Bee Apis mellifera XP_394997 405 45681 L246 P P P A A T R L D A A L V K M
Nematode Worm Caenorhab. elegans P34567 376 41593 H231 S V A L D P D H L Q L L F S K
Sea Urchin Strong. purpuratus XP_782325 476 53839 T246 P P P A R V N T E P S P I R M
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04673 461 52272 V310 E A V T P L P V N K I N K G F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 99.7 98.2 N.A. 96.9 96.4 N.A. 77.8 N.A. 84 81 N.A. 49 50.1 42.2 50.6
Protein Similarity: 100 100 100 98.9 N.A. 97.9 97.4 N.A. 80.8 N.A. 93.4 91.1 N.A. 65 69.1 62.5 63.4
P-Site Identity: 100 100 100 100 N.A. 100 93.3 N.A. 100 N.A. 100 100 N.A. 60 40 6.6 60
P-Site Similarity: 100 100 100 100 N.A. 100 93.3 N.A. 100 N.A. 100 100 N.A. 73.3 80 6.6 73.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.4 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 86 15 0 0 0 0 8 8 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 65 0 0 0 0 0 % C
% Asp: 0 0 0 0 8 0 8 0 8 0 0 0 0 0 0 % D
% Glu: 8 0 0 0 0 0 0 0 72 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 8 % F
% Gly: 0 0 0 0 0 0 8 0 0 0 0 0 0 8 0 % G
% His: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 79 0 0 % I
% Lys: 0 0 0 0 0 8 0 0 0 8 0 0 8 8 8 % K
% Leu: 0 0 0 8 0 8 0 8 8 0 8 86 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 86 % M
% Asn: 0 0 0 0 0 0 8 0 8 8 0 8 0 0 0 % N
% Pro: 86 86 86 0 8 8 8 0 0 8 0 8 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 8 0 8 0 0 0 0 0 0 79 0 % R
% Ser: 8 0 0 0 65 65 58 65 0 0 79 0 0 8 0 % S
% Thr: 0 0 0 8 0 8 8 8 0 0 0 0 0 0 0 % T
% Val: 0 8 8 0 0 8 0 8 0 0 0 0 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _