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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RAPGEF1
All Species:
23.64
Human Site:
T187
Identified Species:
57.78
UniProt:
Q13905
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13905
NP_005303.2
1077
120548
T187
E
D
K
E
M
V
T
T
V
K
G
V
I
K
A
Chimpanzee
Pan troglodytes
XP_001167771
1077
120453
T187
E
D
K
E
M
V
T
T
V
K
G
V
I
K
A
Rhesus Macaque
Macaca mulatta
XP_001105413
1095
122595
T205
E
D
K
E
M
V
T
T
V
K
G
V
I
K
A
Dog
Lupus familis
XP_548407
1288
143146
T345
E
D
K
E
T
V
T
T
V
K
G
V
I
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P27671
1262
144083
D325
W
P
T
L
V
L
A
D
L
F
D
I
L
L
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506600
1390
155369
T353
E
D
K
E
M
V
T
T
V
T
G
V
I
K
A
Chicken
Gallus gallus
XP_415456
1091
122977
T200
E
D
K
E
M
V
T
T
V
K
D
V
I
K
A
Frog
Xenopus laevis
NP_001085772
1035
117343
S185
E
H
P
S
P
T
T
S
T
K
P
S
L
P
A
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O77086
1571
172053
E417
E
C
A
S
L
S
N
E
N
V
R
E
V
I
D
Honey Bee
Apis mellifera
XP_393346
1176
130178
V184
S
A
L
D
T
E
N
V
T
H
I
I
G
L
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
95.8
75.1
N.A.
20.4
N.A.
N.A.
69.5
84.6
77.4
N.A.
N.A.
28
34.5
N.A.
N.A.
Protein Similarity:
100
99.6
96.3
78.8
N.A.
38.5
N.A.
N.A.
72.3
89.6
84.1
N.A.
N.A.
43.2
51.2
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
0
N.A.
N.A.
93.3
93.3
26.6
N.A.
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
33.3
N.A.
N.A.
93.3
93.3
40
N.A.
N.A.
20
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
0
10
0
0
0
0
0
0
0
70
% A
% Cys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
60
0
10
0
0
0
10
0
0
20
0
0
0
10
% D
% Glu:
80
0
0
60
0
10
0
10
0
0
0
10
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
50
0
10
0
0
% G
% His:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
10
20
60
10
0
% I
% Lys:
0
0
60
0
0
0
0
0
0
60
0
0
0
60
0
% K
% Leu:
0
0
10
10
10
10
0
0
10
0
0
0
20
20
0
% L
% Met:
0
0
0
0
50
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
20
0
10
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
10
0
0
0
0
0
10
0
0
10
10
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
10
0
0
20
0
10
0
10
0
0
0
10
0
0
0
% S
% Thr:
0
0
10
0
20
10
70
60
20
10
0
0
0
0
0
% T
% Val:
0
0
0
0
10
60
0
10
60
10
0
60
10
0
10
% V
% Trp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _